Exploring the Causal Role of Mitochondria-related Genes in Parkinson’s Disease through Multi-Omics Mendelian Randomization
Objective: To investigate the causal roles of mitochondria-related gene expression in the pathogenesis of Parkinson's Disease (PD). Background: Mitochondria-related gene expression has been implicated in…SIRT3 upregulation in nigral dopaminergic neurons preserves motor circuit integrity for anti-sarcopenia
Objective: To determine whether enhancing resilience of substantia nigra dopaminergic neurons preserves motor circuit integrity. Background: Degeneration and dysfunction of substantia nigra pars compacta (SNpc)…Phase 2 Trial for the Treatment of Early-stage Parkinson’s Disease with TJ0113, a Small Molecule Mitophagy Activator
Objective: To investigate the efficacy and safety of TJ0113 for patients with early-stage Parkinson's disease. Background: Mitochondrial dysfunction, particularly decreased mitophagy, may contribute to the pathogenesis of…Study on the Mechanism of SIRT3 Protecting Parkinson’s disease by Regulating Mitophagy
Objective: To clarify the protective effect of SIRT3 on Parkinson's disease (PD) and the molecular mechanism by which it regulates mitophagy. Background: PD involves movement…Deep Learning-Driven Discovery of Mitochondrial Genomic Instability in Parkinson’s Disease: A Single-Cell Multi-Omics Approach
Objective: This study integrates snRNA-seq and proteomic data to (i) map mtDNA heteroplasmic mutations at single-cell resolution, (ii) identify mitochondrial-driven transcriptional dysregulation, and (iii) classify…Arginase2 – a potential mediator in the pathology of the stratum
Objective: To investigate the effects of arginase 2 (Arg2) loss on the striatal mitochondria. Background: Arginase plays a role in the production of various metabolites…Organoid-Based AI Clinical Trial Platform for Phase 0 Studies in Parkinson’s Disease
Objective: we developed an organoid-based AI-driven platform to classify patient specific molecular subtypes and predict drug efficacy through an AI-powered validation pipeline. Patient-derived induced pluripotent…Differential Effect of alpha-Synuclein on Mitochondrial Morphology in PD and MSA
Objective: In this study, we investigated the morphology of mitochondria and localization of alpha-synuclein as driven by alpha-synuclein isolated from PD and MSA brain-derived tissue.…Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO), A Novel Retinal Mitochondrial Biomarker For Parkinson’s Disease
Objective: Using fluorescence-lifetime ophthalmoscopy (FLIO), we identified retinal mitochondrial changes in Parkinson’s disease (PD) patients compared to controls. Background: FLIO, a novel non-invasive, in vivo…Neuroprotective role of baicalein via autophagy mediated modulation of associated motor proteins in experimental animals of Parkinson disease
Objective: To evaluate neuroprotective role of baicalein via autophagy mediated modulation of associated motor proteins in rotenone induced mice model of Parkinson disease. Background: Parkinson's…
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