Cognitive Reserve and Physical Activity Modulate Functional Brain Re-organisation in Premanifest Huntington’s Disease: Preliminary Evidence
Objective: In this study, for the first time we examined the relationship between cognitive reserve, sleep quality and current level of physical exercise and functional…MANF improves the MPP+/MPTP-induced Parkinson’s disease via improvement of mitochondrial function and inhibition of oxidative stress
Objective: This study aimed to investigate the therapeutic effect of mesencephalic astrocyte-derived neurotrophic factor (MANF) on the MPTP/MPP+-induced model of Parkinson's disease (PD) and the…Cognitive effects of SIRT6 overexpression: Emerging role of astrocytes
Objective: The aim of this work was to elucidate the effect of SIRT6 overexpression on cognition. Background: Recent evidence show that astrocytes are important for higher brain…Investigating the role of microRNA biogenesis pathway in neuroprotection in primary neuronal culture model of Parkinson’s disease
Objective: Here we study the effect of microRNAs (miRs) biogenesis on the dopamine (DA) neuronal maintenance and protection from different stressor-induced insults. Background: Despite many…Ginsenoside Rb1 protects dopaminergic neurons through Foxm1-Nurr1 pathway in mice model of Parkinson’s disease
Objective: In the present work, we investigated the protective effects of ginsenoside Rb1 in dopaminergic neurons through Foxm1-Nurr1 pathway in mice model of Parkinson’s disease.…Neuromodulatory properties of flavonoids from Persea americana Peel: Role in CNS redox homeostasis and neurobehavioral markers
Objective: Isolating flavonoids from Peel of Persea americana fruits & testing their effects on CNS redox homeostasis culminating in neurobehavioural amelioration among rats. Background: Cellular…Neuromodulatory propensity of Ginko biloba to offset rotenone induced behaviour and biochemical alteration
Objective: The aim of present study was to evaluate neuromodulatory propensity of Gingko Biloba in rotenone induced Mice Model of Parkinson Disease in terms of…Piper betle L. Attenuates 6-OHDA Induced Apoptosis in SH-SY5Y Cells and Neuronal Injury in Caenorhabditis elegans Parkinson’s Model
Objective: To explore the anti-apoptotic effects of Piper bitle leaf extract (PLE) on 6-OHDA induced cellular injury in human neuroblastoma cell SH-SY5Y. To analyse the neuroprotective…Role of Apocyanin in modulating glial cell functions and associated inflammatory response in Lipopolysaccharide induced Parkinson’s disease model.
Objective: To explore the effect of apocyanin on glia mediated inflammatory response and α-synuclein aggregation in single intranigral LPS induced PD model Background: Converging lines…MANF protects dopamine neurons and locomotion defect from Neurotoxin/Human alpha-synuclein-induced progressive Parkinson’s disease models in C.elegans.
Objective: To study whether Mesencephalic astrocyte-derived neurotrophic factor (MANF) has beneficial effects in parkinson disease and its intracellular mechanisms. Background: The distinguishing feature of Parkinson’s…
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