A 6-month Pilot Study of Disease-Modifying Potential of Long-term Transcutaneous Auricular Vagus Nerve Stimulation in Parkinson’s Disease
Objective: To investigate the efficacy and potential disease-modifying effects of of long-term transcutaneous auricular vagus nerve stimulation(taVNS) in patients with early-stage Parkinson's Disease(PD). Background: PD currently lacks established disease-modifying…Multisite high-definition gamma-tACS combined with rhythmic auditory cued gait enhances network efficiency in patients with Parkinson’s disease
Objective: The study aimed to determine whether high-definition gamma-tACS (hd-γtACS) delivered over the posterior parietal cortex (PPC)-primary motor cortex (M1) and cerebellum (CB)-M1 pathways during…Transcutaneous Spinal Cord Stimulation in Hereditary Spastic Paraplegias
Objective: To assess transcutaneous spinal cord stimulation (tSCS) as a treatment for hereditary spastic paraplegias (HSPs). Background: Hereditary spastic paraplegias (HSPs) are genetic disorders characterized…Implementing Adaptive Deep Brain Stimulation in Parkinson’s Disease: A Multimodal Mixed-Methods Evaluation of a Pragmatic Clinical Workflow
Objective: The objective of this study is to evaluate a pragmatic clinical workflow and real-world implementation of adaptive Deep Brain Stimulation (aDBS) through integrated clinical,…Posterior tibial nerve Stimulation in the management of Urinary Disorders in Parkinson’s Disease Experience of the National Hospital Center of Pikine
Objective: Evaluate the efficacy of posterior tibial nerve stimulation in the management of LUTS in patients with PDCompare posterior tibial nerve stimulation to medication Background:…Therapeutic effects of intermittent theta-burst stimulation on motor, non-motor symptoms and functional connectivity in de novo Parkinson’s disease
Objective: To evaluate the clinical and resting-state functional connectivity effects of bilateral M1-iTBS in patients with de novo Parkinson’s disease. Background: Dopaminergic neurodegeneration in Parkinson’s…Sustained Benefit of a Wrist-Worn Vibratory Wearable on Upper Limb Essential Tremor
Objective: This retrospective analysis evaluates the cumulative, sustained effects of a wrist-worn vibratory stimulator over time by examining baseline change over each randomization period, day-over-day…Neural Mechanisms of Intermittent Theta Burst Stimulation for Depressive Symptoms in Parkinson’s Disease: Insights from fNIRS-Based Cortical Activation and Connectivity Dynamics
Objective: This study investigated the neural mechanisms underlying the effects of intermittent theta burst stimulation (iTBS) on depressive symptoms in Parkinson’s disease (PD-D) using functional…Safety and Efficacy of a Wrist-Worn Vibratory Stimulator for Upper Limb Tremor Reduction in Essential Tremor (ULTRE): A Randomized, Controlled Trial
Objective: To assess the safety, tolerability, and efficacy of a wrist-worn vibratory stimulator by comparing two active paradigms (Pulsed (AP), Continuous (AC)) to Sham in…Investigation of the mode of action of a new device for the application of therapeutic vibro-tactile stimulation to the fingertips on brain activity
Objective: The development of a new therapeutic glove for the vibro-tactile stimulation of the fingertips was accompanied by investigations on its mode of action on…
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