Sex-related longitudinal change of motor features and biological biomarkers in early Parkinson’s disease from the PPMI cohort
Objective: We aim to describe sex-related longitudinal changes in (1) motor features and motor aspects of experiences of daily living and (2) biologic measures as…Increased expression of conexin 36 in rodent model of Parkinson disease
Objective: To evaluate changes in non-synaptic mechanisms associated with the procedures to reproduce the neurophysiological conditions typical of Parkinson's disease (PD). Background: Many mechanisms that…Alpha-synuclein preformed fibril (PFF)-triggered synucleinopathy recapitulates neurochemical features of human PD: A PET study in rats
Objective: To investigate longitudinal dopaminergic deficits and similarity to human Parkinson’s disease (PD) using PET imaging in the rat alpha-synuclein (a-syn) preformed fibril (PFF) model.…Genetic Profiling of Early Synucleinopathy in Rat Nigrostriatal Dopamine Neurons
Objective: Identification of changes in gene expression in rat nigral neurons associated with early phases of synucleinopathy. Background: Early phases of synucleinopathies such as Parkinson’s…In vivo imaging of presynaptic terminal loss in early Parkinson’s disease
Objective: To determine the magnitude and anatomical extent of presynaptic terminal damage in early Parkinson’s disease (PD) in vivo, we performed a PET study with…Novel Mutation of NUS1 Gene Presenting With Developmental And Epileptic Encephalopathy and Movement Disorders
Objective: To report the range of movement disorders associated with a NUS1 gene mutation. Background: To date, pathogenic loss-of-function de novoNUS1mutations have been described in only…Striatal dopaminergic regulation of micrographia in parkinsonism
Objective: To investigate the role of brain dopamine function in writing and drawing micrographia of patients with parkinsonism. Background: Micrographia, an abnormally small or progressively…Glabellar tap predicts dopamine transporter deficiency in parkinsonism
Objective: The objective of this study was to investigate the association between glabellar tap findings with nigrostriatal dopamine function in patients with unclear parkinsonism. Background:…Correlation between striatal CIT uptake and Mini-Mental State Examination in Parkinson’s disease
Objective: This study was performed to identify any relationship between the amount of decline of receptor uptake of CIT and Mini-Mental State Examination(MMSE) score in…Therapeutic intervention of LRRK2 kinase inhibitors in Vps35 p.D620N Parkinsonism
Objective: To explore the therapeutic potential of LRRK2 kinase inhibitors in a Vps35 p.D620N mouse model of Parkinsonsim. Background: The discovery of a missense mutation, Vps35 p.D620N…