The Oral Metagenome and Metatranscriptome of Early Stage Parkinson’s Disease and their Relationship with Clinical and Functional Outcome Measures of Motor and Nonmotor Function
Objective: To identify sensitive and specific biomarkers of changes in the oral microbiome of subjects with early stage Parkinson’s Disease and relate these to clinical,…Glabellar tap predicts dopamine transporter deficiency in parkinsonism
Objective: The objective of this study was to investigate the association between glabellar tap findings with nigrostriatal dopamine function in patients with unclear parkinsonism. Background:…Longitudinal progression of spatiotemporal parameters of turning in idiopathic Parkinson’s disease patients with Freezing of Gait
Objective: To develop predictive algorithms for freezing of gait (FOG) in Parkinson’s disease (PD) using longitudinal objective assessment of turning behaviors. Background: Freezing of Gait…Parkinsonism and rapidly progressive dementia secondary to free-living ameba
Objective: Present an original case description of a patient with amebic meningoencephalitis. Background: Parkinsonism could be caused by degenerative disorders, brain injuries, drugs, toxins, and…Postural instability secondary to hypoxic injury to the bilateral globus pallidi
Objective: To describe a case of post-hypoxic postural instability associated with bilateral internal globus pallidi (GP) infarcts. Background: A variety of movement disorders, including parkinsonism,…Structural connectivity changes in prodromal Parkinson’s disease patients: a multimodal MRI study
Objective: We hypothesised that changes in the brain structure and connectivity would be present at this stage. Background: There is wide consensus that prolonged prodromal…Functional mobility tests and their relationship with disease stage in patients with Parkinson’s Disease
Objective: The main objective of this study is set as to determine the relationship between several Functional Mobility Tests (FMT) and disease stages in patients…Measuring progression of nigrostriatal degeneration in Parkinson’s disease using 18F-AV-133 vesicular monoamine transporter type-2 (VMAT2) PET
Objective: To evaluate the progression of nigrostriatal degeneration in participants with Parkinson’s disease (PD) using 18F-AV-133 vesicular monoamine transporter type-2 (VMAT2) PET. Background: Vesicular monoamine…Ambroxol treatment of primary macrophages derived from patients with GBA-associated Parkinson’s disease
Objective: The aim was to evaluate the effectiveness of the restoration of GCase activity in macrophages from GBA-PD patients using pharmacological chaperone ambroxol. Background: Mutations…Blood–brain barrier breakdown in an adult mouse model of Parkinson’s disease
Objective: This study aims to evaluate the integrity of the blood-brain barrier (BBB) in parkinsonism. Background: Parkinson's disease (PD) is a neurodegenerative disorder which is…
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