Relationship between the presence of colonic a-synuclein and MDS research criteria for prodromal PD in patients without manifest motor parkinsonism (PARCAS study)
Objective: The aim of the study was to assess the prevalence of prodromal PD based on the MDS research criteria in a population of patients…Evaluation of CSF cytokine profiles in people with Parkinson disease and age-matched controls.
Objective: To investigate the levels of cytokines in the cerebrospinal fluid of subjects with Parkinson disease (PD) and matched healthy controls. Background: Neuroinflammation is thought…Non-Invasive Assessment of Swallowing and Respiration Coordination in Early Parkinson’s Disease
Objective: To investigate swallowing and its coordination with respiration in patients with Parkinson’s disease. Background: Patients with Parkinson’s disease usually present with speech and swallowing…Design and discovery of 1,2,4 triazole derivatives as adenosine A2A receptor antagonist against parkinson’s disease
Objective: In the present study, we intended to develop novel 1,2,4 triazole as potent A(2A)AR antagonists against parkinson’s disease. Background: Parkinson’s disease (PD) is a…Treatment of secondary movement disorders related to midbrain cavernomas
Objective: To evaluate possible efficacy and safety of standard antiparkinsonian drugs (levodopa formulations, amantadine) in patients with symptomatic midbrain cavernomas (haemorhage and/or surgery) and secondary…Piperine potentiate the neuroprotective effect of quercetin against MPTP induced neurotoxicity in rats
Objective: (1) Quercetin is well tolerated bioflavonoid used as supplement for various disorders but problem is its low oral bioavailability and (2) Piperine is combined…The clinical profile associated to Amyloid-beta 42 and Tau cerebrospinal fluid levels in non-demented PD patients
Objective: To define cerebrospinal fluid (CSF) levels of Amyloid-beta 1-42 (Aß1-42-), total (h-) and phosphorylated (p-)Tau in a large cohort of non-demented Parkinson’s disease (PD)…Interval from onset of Parkinson disease to onset of motor and non-motor complications in Leucine-rich repeat kinase 2 (LRRK2) G2019S positive versus matched PD controls
Objective: To compare the latency between onset of Parkinson disease (PD) symptoms and onset of motor and non-motor complications of PD, between G2019S LRRK2 mutation…Genetic, epigenetic and expression profiles in alpha-synucleinopathies
Objective: To determine whether each of the alpha-synucleinopathies has distinct methylation and/or expression profiles that distinguishes them from other disorders in this class. Background: The…Baseline Clinical Predictors of Future Psychotic Symptoms in de novo Parkinson Disease
Objective: To determine which baseline clinical symptoms are associated with future psychotic symptoms in de novo Parkinson disease (PD). Background: Because psychosis in PD is…
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