Pallidotomy Reborn? Revisiting GPi Lesions in the Era of Neuro modulation for Parkinson’s Disease
Objective: To compare motor outcomes, surgical considerations, and follow-up data between unilateral GPi-DBS and GPi-RF pallidotomy in Parkinson’s disease (PD), evaluating their long-term efficacy and…Vitamin D3 Supplementation Ameliorates Non-Motor Symptoms Associated with Parkinson’s Diseases in a Rotenone Model in Wistar Rats
Objective: This study investigated the role of VD3 supplementation on non-motor symptoms and its mechanism of action in a rotenone rat model of PD. Background:…Body Composition and Resting Metabolic Rate in Parkinson’s disease-A Cross Sectional Study
Objective: To study the body composition and resting metabolic rate in patients with PD and to compare with healthy controls, disease severity and among motor…The Role of Diet in the Relationship Between Hyposmia and Constipation in Patients with Parkinson’s Disease
Objective: To assess the relationship between diet in the relationship between non-motor symptoms in Parkinson’s disease (PD). Background: While the etiology of PD is not…Fatigue in Parkinson’s Disease: A Case-Control Cross-Sectional Study in a Rural Indian teaching hospital
Objective: . This study investigates fatigue severity, demographic/clinical correlates, and gender differences in Parkinson's Disease(PD) patients compared to age- and gender-matched controls in a rural…Prevalence of Transcobalamin Receptor Antibodies and Relationships with Vitamin B12 and Holotranscobalamin in Parkinson’s Disease
Objective: To measure the prevalence of serum transcobalamin receptor antibodies (CD320ab) in a large cohort of patients with early Parkinson’s disease(PD) and to assess their…Evaluating the Efficacy of Virtual Reality Simulations in Enhancing Balance Recovery Among Older Adults: A Systematic Review Using Statistical Modeling
Objective: To systematically evaluate the effectiveness of virtual reality (VR) simulations in enhancing balance recovery among older adults through statistical modeling. Background: Age-related declines in…Deep Learning-Driven Discovery of Mitochondrial Genomic Instability in Parkinson’s Disease: A Single-Cell Multi-Omics Approach
Objective: This study integrates snRNA-seq and proteomic data to (i) map mtDNA heteroplasmic mutations at single-cell resolution, (ii) identify mitochondrial-driven transcriptional dysregulation, and (iii) classify…First preliminary Experience of Tele-medicine in Deep Brain Stimulation in Middle East
Objective: Assessment of application of tele-medical DBS in patients with Parkinson's disease in Egypt and Middle East countries Background: If DBS is determined to be…Clinical validity of a digital toolkit combining active and passive assessments in early Parkinson’s Disease
Objective: We evaluated clinical validity of smartphone-administered active assessments and passive measures of motor function in early Parkinson’s Disease (PD) designed for in-home remote use.…
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