Prediction of turning characteristics parameters into Parkinson’s disease
Objective: To investigate the parameters predicting turning dysfunction in individuals with Parkinson’s disease (PD). Background: Turning deficit in PD has significant implications particularly regarding increase…Apolipoprotein E e4 genotype affects early motor progression in Parkinson’s disease through an effect on cognition
Objective: To evaluate the relationship between APOE e4 genotype, cognition, and motor progression in early Parkinson’s disease (PD). Background: The Apolipoprotein E (APOE) e4 genotype…Chronic pain and the polytrauma clinical triad are risk factors for prodromal PD
Objective: This study aimed to assess whether chronic pain is a risk factor for prodromal Parkinson disease and determine if pain severity and comorbidity with…Can a single-session of weight-shift training support people with Parkinson’s step from a freeze?
Objective: To assess the efficacy and the safety of a weight-shift (WS) intervention used in a complex and demanding gait context Background: Freezing of gait…Drivers of longitudinal healthcare cost in Parkinson Disease
Objective: To identify associations between baseline patient and disease characteristics, and longitudinal healthcare costs in Parkinson disease (PD). Background: Disease prevalence, disability-adjusted life-years, and PD…Path To Prevention (P2P) Therapeutics Platform Trial in Biomarker Defined Prodromal Parkinson’s Disease: Study Design
Objective: To describe the study design and proposed timeline of the first interventional study in biomarker defined prodromal Parkinson’s Disease (PD). Background: P2P is a…Validation and replication of Parkinson disease behavioral subtypes
Objective: To validate and replicate clinical subtypes of Parkinson disease. Background: We recently identified three distinct clinical subtypes of Parkinson disease: motor (predominant motor with…Pre-operative predominance of Tremor versus PIGD scores in drug OFF state predicts motor and non-motor outcomes of STN-DBS for Parkinson’s disease
Objective: To test the predictive value of predominance of tremor versus PIGD scores on the motor and non-motor outcomes of bilateral STN DBS for Parkinson’s…Integrated safety analysis of BIA-28-6156 phase 1 clinical trials (a novel allosteric activator of beta-glucocerebrosidase)
Objective: To describe the safety profile and tolerability of BIA-28-6156 observed during phase 1 clinical trials. Background: BIA-28-6156 is a novel allosteric activator of beta-glucocerebrosidase…Unveiling the Link between Stress-Related Disorders and Dysautonomic Symptoms in Parkinson’s Disease: A Cross-Sectional Study
Objective: To explore the link between post-traumatic stress disorders and dysautonomic symptoms in Parkinson's disease. Background: Parkinson's disease is a complex condition that can lead…
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