LRRK2 Inhibition by BIIB122: Trial designs for two efficacy and safety studies in Parkinson’s disease patients with and without LRRK2 mutations (Lighthouse and Luma)
Objective: Describe Luma and Lighthouse, two studies that investigate efficacy and safety of BIIB122, a LRRK2 inhibitor. Background: Increased LRRK2 kinase activity has been linked…Level of glial neurotrophic factor in the blood plasma depending on the duration of Parkinson’s disease
Objective: To study the level of glial neurotrophic factor in the blood plasma depending on the duration of PD. Background: Study of the biochemical aspects…Curcumin prevented electrophysiological and behavioral alterations in a rotenone model of Parkinson’s disease
Objective: This study discusses the in vivo electrophysiology of the hippocampus, behavioral correlates after rotenone intoxication. Background: Parkinson's disease is a progressive nervous system disorder…The prevalence of helicobacter pylori in Parkinson’s disease
Objective: to study the association between helicobacteriosis pylori (HP) and patients with Parkinson's disease Background: Helicobacter pylori is a bacterium associated with gastrointestinal diseases and…Quantity detection of Substantia nigra hyperechogenicity based on digital image analysis for diagnosing Parkinson’s disease
Objective: We aimed to apply digital analysis to quantify hyperechogenicity of Substantia nigra, and explore its clinical value for the diagnosis of PD. Background: Increased…Effect of Aspartame on Parkinson’s Disease Progression and Severity
Objective: The purpose of this review was to assess the current evidence regarding the effect of aspartame (APM) consumption on Parkinson’s Disease (PD) severity. Background:…Body-first and brain-first PD animal models mimic human PD subtypes
Objective: Here, we aim to model body- and brain-first PD by injecting pathology in the gut and amygdala of old wild-type rats, respectively. Background: Parkinson’s…The Effect of a Boxing Exercise Program on Laryngeal Function in People with Parkinson’s Disease
Objective: This project aimed to determine the effect of a boxing exercise program on aerodynamic measures related to voice production (maximum expiratory pressure, MEP; transglottal…Chronic administration of bitopertin, a GlyT1 inhibitor, in the dyskinetic 6-OHDA-lesioned rat model of Parkinson’s disease
Objective: To evaluate if, upon chronic administration, tolerance to the anti-dyskinetic effect of the glycine transporter 1 (GlyT1) inhibitor bitopertin, would develop, in the 6-hydroxydopamine…Differences between two cognitive assessment instruments used in Parkinson’s disease in Kyrgyzstan
Objective: The aim of this study was to determine differences between Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) in PD patients from Kyrgyzstan.…
- « Previous Page
- 1
- …
- 328
- 329
- 330
- 331
- 332
- …
- 436
- Next Page »