Optimization of a neuromelanin MRI protocol for use in a longitudinal study of substantia nigra depigmentation in early Parkinson’s Disease (the InsIght-PD study)
Objective: To optimize a neuromelanin-MRI (NM-MRI) protocol for robust and timely change analysis; and acquire serial NM-MRI data in controls and early Parkinson’s Disease (PD),…Five for the price of one- A multidirectional micro-electrode recordings for DBS Surgery
Objective: To examine the use of a multidirectional micro electrode during Deep Brain Stimulation (DBS) surgery for Parkinson's Disease (PD) in 9 patients. Background: Micro-Electrode…Gold and silver nanoparticle-based Localized Surface Plasmon Resonance Sensor (LSPR) for the detection of histidine as a potential biomarker in Parkinson’s Disease.
Objective: Previous literature has proven that histamine has a crucial role in the process of neuroinflammation in Parkinson's Disease (PD) . We can indirectly detect…Remote physical activity monitoring programs for Veterans with Parkinson’s disease
Objective: To examine feasibility of a remote physical activity monitoring program and predictors of activity among rural Veterans with PD Background: Patients in rural areas,…Effect of exercise on motor symptoms, non-motor symptoms and dopamine transporter imaging in Parkinson Disease
Objective: To examine the effect of aerobic exercise on motor symptoms, non-motor symptoms (NMS) and dopaminergic denervation, measured by I-123-ioflupane single photon emission computed tomography…Validation of a patient-reported functional mobility composite score (FMCS) in people with typical Parkinson’s disease
Objective: To investigate the convergent and discriminative validity of a patient-reported FMCS in people with typical PD (PwP). Background: Although a patient-reported instrument is less…Cognitive and Motor aspects of a Brazilian population with Parkinson´s disease and Impulse Control Disorders and/or Related Behaviors – an observational study.
Objective: We analysed if Impulse Control Disorders (ICDs) and/or Related Behaviors (RBs) were associated with levodopa-induced dyskinesia (LIDs) in Brazilian patients with Parkinson´s disease (PD)…Multimodal MRI assessment of the substantia nigra in premotor and motor stages of parkinsonism
Objective: To investigate substantia nigra (SN) MRI abnormalities through Neuromelanin (NM) and diffusion MRI (dMRI) with Neurite Orientation Dispersion and Density Index (NODDI) in the…Assessment of novel diffusion MRI metrics of cortical microstructure in the genetic continuum of Parkinson’s disease
Objective: To investigate novel cortical diffusivity metrics in Parkinson’s disease (PD), including both prodromal and established genetic PD, alongside sporadic PD and healthy controls (HC).…Identifying meaningful symptoms and impacts of disease for patients with early Parkinson’s disease
Objective: To explore meaningful symptoms and impacts of disease on daily living in individuals with early-stage Parkinson’s disease (PD). Background: Critical Path for Parkinson’s (CPP)…
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