Text entry as a digital outcome in Parkinson’s disease patients (TEXT-PD): results from two exploratory studies
Objective: To evaluate the feasibility and psychometric properties of text entry (TE) and touch metrics as digital outcomes for PD patients. Background: TE on smartphones…Evaluation of cases of psychosis from opicapone safety data
Objective: Investigate the likelihood of association of Opicapone (OPC) with psychotic symptoms (other than hallucinations). Background: Neuropsychiatric symptoms frequently occur in Parkinson’s Disease (PD) patients,…Axial impairment and bradykinesia are related to increased CSF sTREM2, a neuroinflammation biomarker, in Parkinson’s disease
Objective: To explore the association between Parkinson’s disease (PD) motor symptoms and CSF biomarkers for neuroinflammation and neurodegeneration. Background: Previous in vivo and post mortem…Diabetes impact on nigrostriatal vulnerability in Parkinson’s Disease
Objective: aim of the study was to investigate whether diabetes mellitus influences nigrostriatal dopaminergic vulnerability in drug-naïve patients with early-stage Parkinson’s Disease (PD). Background: recently,…Combined GWAS of Dementia with Lewy Bodies, REM-Sleep Behavior Disorder, Parkinson’s Disease and Alzheimer’s Disease
Objective: To identify genetic variants that are either shared between or specific for Dementia with Lewy Bodies (DLB), REM Behavior Disorder (RBD), Parkinson’s disease (PD)…Sexual health and sleep quality in women living with Parkinson’s disease: are we neglecting that?
Objective: To investigate the relationship between sexual health and sleep quality in PD. Background: Sexual dysfunction (SD) is a common yet under-reported, non-motor symptom (NMS)…Olfactory neurons’ Substance P is highly expressed in Parkinson’s disease reflecting gastrointestinal dysfunction
Objective: To elucidate the role of Substance P in PD through molecular characterization of patients’ olfactory neurons. Background: Substance P is a neuropeptide largely expressed…Assessing akinesia domains during multitasking in Parkinson’s disease
Objective: To explore performance differences in single- versus dual-tasking conditions between healthy controls (HC) and Parkinson's disease (PD) patients. Background: Akinesia, comprising slowness (bradykinesia), reduction…Spinal cord stimulation for gait in Parkinsons disease in subthreshold settings
Objective: To assess optimal parameters for tonic spinal cord stimulation (SCS) for Parkinson’s Disease (PD) gait disorders in blinded settings. Background: SCS is a promising…Associations of IL-1β and IL-6 gene polymorphisms with Parkinson’s disease(PD)
Objective: We aim to explore the associations of IL-1β and IL-6 gene polymorphisms with the pathogenesis of PD and with clinical features of motor and…
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