The mitochondrial risk score and lifestyle factors are associated with age at onset in LRRK2 p.Gly2019Ser Parkinson’s disease.
Objective: To investigate the relationship between a mitochondrial risk score (MRS), lifestyle and age at onset (AAO) in LRRK2 G2019S Parkinson’s disease (PD). Background: PD…Inflammatory microglial and astroglial phenotype associated with pathological alpha-synuclein inclusions in the substantia nigra
Objective: To characterize neuroinflammatory gene expression in microglia and astrocytes associated with early alpha-synuclein (a-syn) inclusion formation. Background: Parkinson’s disease (PD) is characterized by alpha-synuclein…Protective mechanism of melatonin via heat shock protein in the MPP+-induced in vitro Parkinson’s disease model
Objective: The objective of this study was to investigate the protective properties of melatonin in an in vitro Parkinson’s disease (PD) model, especially focusing on…Month 24 results of a virtual longitudinal, observational study of Parkinson’s disease: The AT-HOME PD cohort
Objective: To describe the change in characteristics of Parkinson’s disease (PD) clinical trial participants over 24 months following trial participation in a remote, longitudinal observational…Examining the sex differences in the prevalence and incidence of Parkinson disease
Objective: The objective of this meta-analysis was to examine the male-to-female (M/F) incidence and prevalence of Parkinson disease. Background: Parkinson disease (PD) is a major…Novel bi-allelic variants in FBXO7 in a family with young-onset typical Parkinson’s disease
Objective: To describe the case of two brothers affected by typical young-onset Parkinson’s disease (PD), carrying novel compound heterozygous variants in FBXO7. Background: Bi-allelic mutations…Prevalence, clinical and neuropsychiatric aspects of Sleep Disorders in Parkinson’s disease: a meta-analysis
Objective: The present meta-analysis aims to provide a reliable estimate of the prevalence and associated clinical and neuropsychiatric aspects of the most frequent sleep disorders…Closing the gap: Increasing access to genetic testing and counseling for Hispanics through PD research
Objective: To report preliminary genetic findings of Hispanic participants from the PD GENEration Registry and GEN-EP Latino study. Background: The incidence of Parkinson disease across…Performance of Parkinson´s disease cognitive scale rating scale (PD-CRS) after 2 years Subthalamic nucleus deep brain stimulation. Comparison with Mattis Dementia Rating Scale (MDRS) and Mini-Mental State Examination (MMSE)
Objective: To study the performance of PD-CRS before and 2 years after STN-DBS and compare their results with other recognized cognitive scales. Background: Parkinson´s disease…Diagnostic Utility of I123-FP-CIT Single Photon Emission Computed Tomography for Patients with Clinically Uncertain Parkinsonian Syndrome
Objective: This study investigated the impact of I123-FP-CIT single photon emission computed tomography (SPECT) for the diagnosis of patients with clinically uncertain parkinsonian syndrome (CUPS)…
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