Statistical methods for dealing with missing data in longitudinal studies with application to Parkinson’s disease cognition research
Objective: To assess the performance of standard techniques for handling missing data in longitudinal studies under a variety of missing data scenarios. We demonstrate our…α-Synuclein in sympathetic nerve fibers distinguishes PRKN from LRRK2 and other genetic forms of Parkinson’s Disease
Objective: This cross-sectional observational study compared magnitudes of intra-neuronal deposition of α-synuclein in common and rare genetic forms of Parkinson’s disease. Background: Cytoplasmic inclusions of…Lack of diversity in Parkinson’s disease genetic research: current landscape and future directions
Objective: We conducted a systematic review to summarize past studies on Parkinson's disease (PD) genetics research among underrepresented populations (URP), defined as being non-European ancestry. We…MicroRNAs as a potential biomarker of Parkinson’s disease
Objective: Our study was aimed at analyzing the role of microRNA as a potential biomarker of PD. Background: A substantial part of cases of Parkinson’s…VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease
Objective: To establish the pathogenic effects of the PD-causing VPS35 D620N mutation in vivo and address possible underlying mechanisms. Background: D620N mutation in the vacuolar…Changes in brain functional connectivity after cognitive behavioral therapy for anxiety in Parkinson’s disease: a longitudinal MRI study.
Objective: To identify changes in brain functional connectivity (FC) after Cognitive Behavioral Therapy (CBT) for anxiety in patients with Parkinson’s disease (PD). Background: Recently we…Longitudinal changes in nigral neuromelanin in early, levodopa-treated Parkinson’s disease
Objective: To assess longitudinal changes in neuromelanin (NM) content in the substantia nigra compacta (SNc) and its lateral-ventral subregion in Parkinson’s disease (PD). Background: NM-sensitive…Reduced cerebral energy metabolism in Parkinson’s disease in contrast to Progressive Supranuclear Palsy
Objective: To determine the significance of 31P-MRSI to differentiate between idiopathic Parkinson’s disease (PD), Progressive supranuclear palsy (PSP), and healthy control subjects. Background: Bioenergetic disturbances,…The role of network connectivity in shaping the progression of cortical atrophy in Parkinson’s disease
Objective: We aimed to map the progression of cortical thinning and to test whether this pattern is constrained by network connectivity in the brain. Background:…Emotional stress exacerbates parkinsonian resting tremor
Objective: To examine the role emotions may play in modulating the characteristics of parkinsonian resting tremor. Background: There is ample evidence showing cognitive stress can…
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