Item – Level Drivers of Certification Failure in the MDS-UPDRS Motor Examination: A Five-Year Global Analysis
Objective: To identify individual Part III items that disproportionately contribute to first-attempt certification failure and to evaluate the stability of these patterns over five years.…Clinical instability and fluctuations as an early marker of accelerated progression
Objective: To determine whether early clinical instability, quantified through combined motor and non-motor fluctuations, predicts a more severe longitudinal disease course in Parkinson’s disease. Background:…Exploring a Milestone-Based Approach as an Outcome Measure for Disease-Modifying Parkinson Disease Trials
Objective: To replicate a composite milestone(CM) approach in a range of Parkinson Disease(PD) studies(observational, clinical trials) over a long time period(up to 12 years). To…Associations Between FDG-PET Regional Metabolism and Clinical Severity in Progressive Supranuclear Palsy
Objective: To characterize the clinical profile, disease progression, and their associations with neuroimaging biomarkers in patients with Progressive Supranuclear Palsy (PSP). Background: PSP encompasses a…Patient-Defined Disease Progression in Parkinson Disease: Towards Patient-Relevant Outcome Measures
Objective: To carry out a survey on a representative sample of people with Parkinson’s (PwP) about their lived experience of a comprehensive list of Parkinson…Beyond Motor Outcomes: Health Literacy, Medication Adherence, and Quality of Life in Parkinson’s Disease Patients Undergoing the Levodopa Challenge Test
Objective: To characterize health literacy (HL), medication adherence, satisfaction with medication information, and quality of life (QoL) in Parkinson’s disease (PD) patients undergoing the levodopa…Prospective Evaluation of a Video-Based Motor Assessment Workflow: Feasibility, Usability, and Data Quality
Objective: To prospectively evaluate the feasibility, usability, and data quality of a video-based motor assessment platform (PRIMS) in a clinic setting, and to examine agreement…Interplay of sex and GBA1 and LRRK2 genotype in Parkinson disease progression
Objective: To characterize disease heterogeneity and how sex impacts motor and cognitive progression class membership across genetic subgroups of GBA1, LRRK2, and idiopathic Parkinson disease (PD). Background: Autosomal…Automating the assessment of motor symptoms of Parkinson’s: exploring the scope of assessment possible in a video-based approach.
Objective: To explore the scope of the PRIMS assessment in People with Parkinson’s (PwP), including symptom severity rating, assessment time, individual assessment item completion and…Clinical Characteristics of Parkinsons Disease and their Role in Differential Diagnosis
Objective: To study and systematize the clinical characteristics of Parkinson's disease (PD) and their role in differential diagnosis with other parkinsonian syndromes. Background: Parkinson’s disease…
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