Neurophysiological markers of motor reserve in Parkinson’s disease
Objective: Our objective was to investigate Motor Reserve (MR) in idiopathic Parkinson’s Disease (PD). Background: MR is defined as the resilience mechanisms of the brain…Brain first-body first: is the dat-scan useful?
Objective: The purpose of this study is to evaluate possible differences in the DAT-SCAN ratios in patients with and without dysautonomia and RBD at diagnosis.…Correlation between Striatal degeneration and Cerebellar fiber alterations of Parkinson’s disease
Objective: We tried to show divisional evaluation of caudate and putamen in [123I] FP-CIT(DAT) -SPECT has use for assessment of PD symptoms and capture the…Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients
Objective: To investigate the association between cerebrospinal (CSF) αS aggregates, MRI, and dopamine transporter spectral tomography (DaTscanTM) imaging metrics. Background: Synuclein amplification assays (SAA) enables…Genetic polymorphisms associated with nigrostriatal dopaminergic depletion as measured with [I123]-FP-CIT SPECT in Parkinson’s disease
Objective: To conduct a genome-wide association study (GWAS) of striatal [I123]-FP-CIT SPECT signal as endophenotype to explore possible associations between genetic background and nigrostriatal dopaminergic…Investigating the use of DAT-SPECT as an enrichment biomarker to determine eligibility for the phase 2 clinical trial PASADENA
Objective: Evaluate dopaminergic imaging DAT-SPECT as an enrichment strategy to avoid inclusion of participants with scans without evidence of dopaminergic deficit (SWEDD) in a Phase…Neuroimaging in Glucocerebrosidase-associated parkinsonism: a systematic review
Objective: To critically review studies applying neuroimaging to Glucocerebrosidase (GBA)-associated parkinsonism. Background: Mutations in the GBA gene cause Gaucher disease (GD) and constitute the most…Gerstmann-Straussler-Scheinker Syndrome Manifesting Levodopa-Responsive Parkinsonism, Levodopa-Induced Dyskinesia, and Abnormal DaT-SPECT
Objective: The objective of this report is to describe previously unreported features in a patient with Gerstmann-Straussler-Scheinker syndrome (GSS) due to the F198S mutation. Background:…Correlation between 3 Tesla Brain MRI Nigrosome-1 imaging and SPECT 123I-Ioflupane in parkinsonian disorders
Objective: To correlate nigrosome-1 (NG1) imaging and SPECT 123I-Ioflopane findings to determine the feasibility and diagnostic value of NG1 imaging in a real-world clinical setting.…Diagnostic Utility of I123-FP-CIT Single Photon Emission Computed Tomography for Patients with Clinically Uncertain Parkinsonian Syndrome
Objective: This study investigated the impact of I123-FP-CIT single photon emission computed tomography (SPECT) for the diagnosis of patients with clinically uncertain parkinsonian syndrome (CUPS)…
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