Serial DaT-SPECT imaging in asymptomatic carriers of LRRK2 G2019S mutation: 8-years follow-up
Objective: To characterize the 8-year progression of clinical and imaging biomarkers in a cohort of asymptomatic LRRK2 G2019S carriers and to assess its utility as predictors of…Reversible MIBG Abnormalities in Subjects at Risk for Synucleinopathy: 12 months data
Objective: To investigate the long-term effects of the adrenergic blocker carvedilol on I-MIBG myocardial uptake in subjects with REM sleep behavior disorder (RBD) and other…Disease stage and nigrostriatal integrity predict motor progression in individuals with early Parkinson’s disease
Objective: To identify predictors of motor progression in individuals with early Parkinson’s disease (PD), who are either untreated or treated with monoamine oxidase B (MAO-B)…Brain SPECT in Patients with Akinetic-Rigid Syndrome Secondary to Radiotherapy
Objective: The aim of this study is to evaluate the results of brain single photon emission computed tomography (SPECT) with 123-iodine ioflupane in patients with brain…Inertial-sensor based full-body kinematics reveals an unstable gait with increased variability in patients with evidence of dopaminergic denervation with 123I-FP-CIT SPECT
Objective: Distinguish patients with and without dopaminergic denervation (as assessed by 123I-FP-CIT-SPECT – DaTscan) with Inertial-sensor full body kinematics (FBK) assessment. Background: The differential diagnosis…Substantianigral involvement on Tc99mDaTSPECT-a novel and under recognised imaging finding in Parkinsonian Disorders
Objective: To assess feasibility of identifying SN involvement on DaTi, correlate with laterality of motor symptoms and compare with loss of nigrosome-1 hyperintensity on SWI . Background:…Comparison of 123I-MIBG myocardial scintigraphy and 123I-FP-CIT SPECT between dementia with Lewy bodies and Parkinson’s disease
Objective: The objective of this study was to compare the nuclear medicine images of dementia with Lewy bodies (DLB) and Parkinson's disease (PD) patients and to extract findings…Quantification of 123I-ioflupane Striatal Uptake and Individual Patient Diagnostic Predictions: Degenerative Parkinson’s disease, Non-Degenerative Parkinsonism and Tremor Disorders
Objective: To develop a fully automated quantitative method to analyse routinely acquired 123I-ioflupane (DaTSCAN) data to aid diagnostic predictions in patients with Parkinson’s disease, non-degenerative…Nigrostriatal degeneration in DYT-PRKRA: new insights on a rare disorder
Objective: To describe a genetically proven DYT-PRKRA (DYT16) case with documented loss of presynaptic dopamine transporters. Background: DYT-PRKRA is an autosomal recessive disorder combining generalized…Asymmetrical striatal dopamine transporter binding correlates with excess contralateral rest tremor
Objective: To investigate the relationship between striatal dopamine transporter binding and rest tremor. Background: In vivo dopamine transporter imaging is a useful tool for distinguishing…
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