Combined STN and NBM DBS in PD and mild to moderate Parkinson’s dementia
Objective: While deep brain stimulation (DBS) of the subthalamic nucleus (STN) alleviates Parkinson"s Disease(PD) related motor symptoms, to date PD dementia (PDD) patients are excluded…Does microelectrode recording increase haemorrhage? A comparative study in a large patient cohort over 20 years
Objective: We aimed to investigate whether there is an increased risk of haemorrhage by using microelectrode recording in a large series of patients operated over…Are transventricular approaches associated with increased haemorrhage in functional stereotactic neurosurgery? A comparative study on 550 patients
Objective: We investigate the comparative occurence of haemorrhage with or without transventricular apporaches in a large series of patients operated over two decades. Background: Accurate…Gamma Knife Radiosurgery for essential and parkinsonian tremor: Long-term experience in a Spanish center
Objective: To describe the experience of a single Spanish center in gamma knife thalamotomy (GKT) as treatment of refractory tremor in patients with Essential Tremor…Magnetic resonance-guided focused ultrasound unilateral thalamotomy for the treatment of essential tremor: Outcomes and complications after 1 year of follow-up in 21 patients
Objective: To report the clinical experience in our center (CINAC-HM Puerta del Sur) in the treatment of essential tremor (ET) with Magnetic Resonance guided Focused…Effect of Post-Operative Symptomatic Lead Edema Associated with Subthalamic Deep Brain Stimulation On Clinical Outcomes
Objective: To assess whether development of post-operative symptomatic edema around deep brain stimulation (DBS) leads impacts clinical outcomes. Background: Post-operative symptomatic delayed edema around the…Controlled neural organoids grafting promotes functional recovery in experimental parkinsonism
Objective: We propose that the striatal transplantation of 3D-neural organoids of controlled cell size and cell content, named "Controlled Neural Organoids" (CNOs), could circumvent the…Blinded acute assessment of electrode contact efficacy compared with contact location for Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease
Objective: This study aimed to assess the clinical efficacy of each contact and the correlation between the clinical best contacts and radiologically defined optimal contacts.…Modified Frameless Stereotaxy for Gene Therapy in Pediatric Movement Disorder Patients
Objective: We have developed a modified frameless stereotaxic system for viral vector delivery of gene therapy in pediatric movement disorder patients with congenital enzyme deficiency.…Biofabricated tissue constructs to recapitulate the anatomy and functionality of the nigrostriatal pathway in Parkinson’s disease
Objective: 1) Biofabricate constructs that mimic the cytoarchitecture and function of the nigrostriatal pathway, and 2) Microinject constructs to assess restoration of dopaminergic input to…
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