Analysis of brain-derived blood exosomes for diagnostics of synucleinopathies
Objective: Here, we aimed to determine if measuring of α-synuclein concentration in these vesicles from oligodendrocytes and neurons can distinguish between patients with MSA or…Motor-based assessment of prodromal Parkinson’s disease combining wearable sensors and machine learning
Objective: To provide the neurologist with a decision support system based on inertial sensors and learning algorithms for an objective early diagnosis of Parkinson’s disease…Extracellular α-synuclein enters dopaminergic neurons by modulating flotillin-1-assisted DAT endocytosis
Objective: In this study, we examine the regulatory role of flotillin-1 in dopamine transporter (DAT) trafficking and the impact of extracellular α-synuclein (αS) on this…Alpha-synuclein interacts with BAF complex in nucleus
Objective: This study aims to uncover the prospective partner of αS in nucleus. Background: In neuronal cells, large part of alpha-synuclein (αS) localize at presynaptic…Self-reported demographic, genetic, symptom, and treatment data of subjects in the Fox Trial Finder
Objective: To examine the characteristics of subjects within the Fox Trial Finder (FTF) database. Background: FTF is an online, patient driven database by which Parkinson’s…Applicability of questionnaires and study of the prevalence of REM Sleep Behavior Disorder (RBD) in Parkinson’s disease
Objective: Evaluation of patients with idiopathic Parkinson's disease regarding the presence of RBD, application of the questionnaires, and correlation between the diagnosis of RBD by…Amplification of α-synuclein aggregates in cerebrospinal fluid by rapid ultrasonication-based assay
Objective: To apply an ultrasonication-based misfolded protein amplification to the evaluation of α-synuclein aggregates in CSF, and to investigate their clinical significances in Parkinson’s disease…Arterial spin labelling detects subcortical hypoperfusion in early drug-naïve patients with Parkinson’s disease
Objective: We evaluated regional cerebral blood flow (CBF) levels in a cohort of early drug-naïve patients with Parkinson’s disease, and we explored for associations between…Fine-mapping of SNCA variants in REM sleep behavior disorder identifies distinct associations
Objective: a). Identify variants in the SNCA locus which affect risk for REM Sleep Behavior Disorder (RBD). b). Test variant effects on rate and type…Evidence of altered Serotonergic Network in Parkinson’s disease by using a multi-modal MRI and PET imaging approach
Objective: This study aims to assess how serotonergic pathological derangement may produce alterations in Parkinson’s disease (PD) functional connectivity, by means of a multimodal neuroimaging…
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