Diffusion Magnetic Resonance Imaging with Neurite Orientation and Dispersion Imaging (NODDI) Detects Early Localized Cortex Disruption in Parkinson’s Disease
Objective: To use diffusion kurtosis MRI with NODDI to assess brain cortex microstructure in Parkinson’s patients and localize disease related changes. Background: Cortical atrophy has…Motor, non-motor and cognitive correlates of carotid intima-media thickness in patients with Parkinson’s disease
Objective: To determine the correlation of carotid intima-media thickness (IMT) to motor, non-motor and cognitive scales in patients with Parkinson’s disease (PD). Background: Increased IMT…Difference in distribution between alpha-synuclein oligomers and Lewy bodies in Parkinson’s disease brain
Objective: To examine the distribution of alpha-synuclein (αSYN) oligomers in Parkinson’s disease (PD) brains and compare the distribution of αSYN oligomers and Lewy bodies. Background:…Ampreloxetine (TD-9855), a long-acting, norepinephrine reuptake inhibitor (NRI) for the treatment of neurogenic orthostatic hypotension (nOH) in subjects with synucleinopathies: Phase 3 clinical program
Objective: To confirm: 1) clinical efficacy and safety of once-daily oral ampreloxetine in a 4-week double-blind (DB), placebo-controlled (PC) study (NCT03750552); 2) durability of efficacy…Identification and characterization of anti-prionic compounds that disassemble αSyn prions as a novel therapeutic approach for synucleinopathies
Objective: Stabilization of monomeric α-synuclein protein (αSyn) by transient and high-affinity binding ligands is a novel and highly innovative anti-prionic treatment strategy for synucleinopathies .…Towards a scoring system to distinguish early parkinsonian variant of multiple system atrophy from Parkinson’s disease
Objective: To develop a clinical score to distinguish between the parkinsonian variant of multiple system atrophy (MSA-P) and Parkinson’s disease (PD). Background: The differential diagnosis…Disease stage and UMSARS progression: Implications for clinical trials
Objective: To study the rate of progression of multiple system atrophy (MSA) and assess for a potential ceiling effect of the Unified Multiple System Atrophy…Alpha-synuclein interacts with BAF complex in nucleus
Objective: This study aims to uncover the prospective partner of αS in nucleus. Background: In neuronal cells, large part of alpha-synuclein (αS) localize at presynaptic…Self-reported demographic, genetic, symptom, and treatment data of subjects in the Fox Trial Finder
Objective: To examine the characteristics of subjects within the Fox Trial Finder (FTF) database. Background: FTF is an online, patient driven database by which Parkinson’s…Applicability of questionnaires and study of the prevalence of REM Sleep Behavior Disorder (RBD) in Parkinson’s disease
Objective: Evaluation of patients with idiopathic Parkinson's disease regarding the presence of RBD, application of the questionnaires, and correlation between the diagnosis of RBD by…
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