Central olfactory structure atrophy is linked to synucleinopathy conversion in idiopathic REM sleep behavior disorder
Objective: We hypothesized that early structural changes in the brain olfactory relevant structures may help early identification of those at risk of future disease conversion…Addressing pathological alpha-synuclein aggregation using a small molecule strategy
Objective: The discovery of cell-permeable, orally bioavailable and brain penetrant small molecules with the potential of inhibiting aggregation and intracellular accumulation of pathological alpha-synuclein (a-syn)…Development of C-terminal α-Synuclein Vaccine for Treatment and Prevention of Parkinson’s Disease and Other Synucleinopathies
Objective: Prothena is developing active vaccine candidates targeting α-synuclein (α-syn) epitopes shown in clinical and/or preclinical studies to disrupt synuclein pathology. These vaccines, which target…The anti-alpha-synuclein antibody Lu AF82422 was safe and well tolerated in a FIH-SAD study in healthy subjects and patients with PD
Objective: Evaluation of safety, tolerability, pharmacokinetics (PK) and target engagement (TE) in healthy subjects (HS) and patients with Parkinson’s disease (PD) following single ascending doses…Remote keyboard tapping: potential signatures of early motor dysfunction in isolated REM sleep behaviour disorder
Objective: To compare keyboard tapping performance in people with iRBD with controls. Background: The Distal Finger Tapping (DFT)1 test and BRadykineisa Akinesia Incoordination test (BRAIN)2…Differential proteomic analysis of plasma exosomes in Parkinson disease associated with mutations in the GBA gene
Objective: To identify the protein changes and to search the potential biomarkers of PD among GBA mutation carriers. Background: Mutations in the GBA gene encoding glucocerebrosidase enzyme are the…Intestinal microbial dysbiosis promotes prebiotic-reversible inflammation in Parkinson’s disease
Objective: To determine the functional effects of disrupted intestinal microbiota in Parkinson’s disease (PD), particularly the impacts of dysbiosis on inflammation, neuroprotective hormone secretion, and…Prevalence and distribution of disease-associated alpha-synuclein in a homeless population
Objective: To study the prevalence and distribution of pathological alpha-synuclein deposition, throughout the central and peripheral nervous systems, in a homeless population. Background: The homeless…Marker Progression and Sample Sizes Estimates for Trials in Prodromal Parkinson’s Disease: A Multicenter Study
Objective: To inform the design of randomized neuroprotective trials in prodromal Parkinson’s disease (PD) by assessing the progression of prodromal markers in idiopathic rapid eye…Relationship between cardiovascular autonomic failure and cognitive performance in the α-synucleinopathies: preliminary cross-sectional analysis of the NHSS registry
Objective: To compare cognitive performances of patients with α-synucleinopathies with or without cardiovascular dysautonomia. Background: Cardiovascular dysautonomia is a disabling non-motor feature of the α-synucleinopathies and may…
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