Single unit activity of medial thalamus during goal-directed motor and cognitive behavior in patients with cervical dystonia
Objective: To 1) study neuronal activity of medial thalamic nuclei (MD, CM-Pf) and its role in cognitive and motor human activity and 2) evaluate neuronal…Modulation of thalamocortical network dynamics via deep brain stimulation in humans with Tourette syndrome
Objective: To (1) investigate the impact on thalamocortical network dynamics in response to low frequency and high frequency deep brain stimulation and (2) uncover the…Effect of intra-striatal 6-OHDA lesion on extra-striatal structures in the mouse
Objective: Characterization of extra-striatal manifestations in the 6-hydroxydopamine (6-OHDA) Parkinson's disease (PD) animal model. Background: PD is a neurodegenerative disorder characterized by progressive loss of…Movement disorders in patients with Japanese encephalitis: Experience in a tertiary care hospital in north eastern region of India
Objective: Movement disorders in Japanese encephalitis is known, but under reported. In this study we tried to analyse the spectrum of movement disorders in patients…Combined pallidal and thalamic stimulation for multifocal primary dystonia with prominent writers’ cramp
Objective: When a patient presents with both writer's cramp and other dystonic symptoms, it is unclear which target should be chosen. Multifocal DBS is a…Increasing placebo response in Parkinson’s disease through apomorphine pre-conditioning
Objective: To see whether a placebo response requires pharmacological pre-conditioning with apomorphine. Background: Placebos have been found to affect the patient's brain in a number…Changes of brain structure and cognition in individuals with possible prodromal Parkinson’s disease
Objective: Investigating brain structure and cognition in healthy individuals with positive Parkinson's disease (PD) risk markers (hyposmia, increased hyperechogenic area of the substantia nigra). Background:…Dopamine reduces Parkinson’s tremor through increased thalamic inhibition
Objective: To identify cerebral mechanisms explaining the effects of dopamine on rest tremor in Parkinson's disease. Background: Resting tremor in Parkinson's disease is related to…