Session Information
Date: Thursday, June 8, 2017
Session Title: Parkinson's Disease: Neuroimaging And Neurophysiology
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: The aim of this study was to describe the cerebral metabolic PET substrate and related connectivity changes in Parkinson’s disease patients with impulse control disorders
Background: Impulse control disorders (ICDs) in Parkinson’s disease (PD) are difficult to diagnose and challenging to manage. Functional studies have shown that these ICDs are linked to overstimulation of the mesocorticolimbic reward system by dopaminergic treatments. However, the exact pathophysiology of ICDs in Parkinson’s disease remains partly unknown. The involvement of a network larger than the mesocorticolimbic system has recently been suggested.
Methods: Eighteen PD patients with ICDs and 18 PD patients without ICDs were evaluated using cerebral 18F-fluorodeoxyglucose positron emission tomography. Using SPM8, SPM-T maps comparisons were performed between groups. Metabolic connectivity of previously identified areas was evaluated by means of an interregional correlation analysis method using correlation coefficients of mean values of the cerebral metabolic rate of glucose consumption extracted at the individual level.
Results: Patients with ICDs had had a relative increased metabolism in the right middle and inferior temporal gyri compared to those without ICD (p<0.005, uncorrected, k>130). The connectivity of this area was increased with the right associative posterior junction and dorsolateral frontal cortex extended to the orbitofrontal region (p<0.005, uncorrected, k>130). We also found a decrease in connectivity with the left caudate and with the right parahippocampal gyrus (p<0.005, uncorrected, k>130).
Conclusions: This study showed that addictive behaviors in Parkinson’s disease are associated with the dysfunction of a vast network largely exceeding the mesocorticolimbic system and including temporal and parietal regions. We hypothesize that the latter are particularly involved in the establishment of a mnemonic component of addiction.
To cite this abstract in AMA style:
E. Robin, A. Verger, F. Fluchere, T. Witjas, J.P. Azulay, E. Guedj, A. Eusebio. Brain PET metabolic substrate of Impulse Control Disorders in Parkinson’s Disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/brain-pet-metabolic-substrate-of-impulse-control-disorders-in-parkinsons-disease/. Accessed October 31, 2024.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/brain-pet-metabolic-substrate-of-impulse-control-disorders-in-parkinsons-disease/