Objective: This study was performed to identify any relationship between the amount of decline of receptor uptake of CIT and Mini-Mental State Examination(MMSE) score in Parkinson’s disease.

Background: Dopamine receptor imaging is useful in the diagnosis of Parkinson’s disease. We want to know whether the degree of striatal uptake of CIT can expect the degree of cognitive decline in patients with Parkinson’s disease.

Method: Fifty-one patients with Parkinson’s disease were recruited from the CIT-PET registry of Daegu Catholic University Medical Center. Diagnosis of Parkinson’s disease was based on United Kingdom Parkinson’s Disease Brain Bank Criteria and the result of CIT-PET. The striatum was divided into 4 parts; right caudate nucleus, left caudate nucleus, right putamen, left putamen. Uptake of CIT were measured with visual assessment by a nuclear physician and the scores were summed in each patient. Cognitive symptoms were measured with MMSE by neuropsychologist. We investigated any correlation between the sum of CIT uptake and the score of the cognitive screening using statistical analysis.

Results: There was a positive correlation between the decline of CIT uptake and MMSE score(P<0.05).

Conclusion: We found decline of striatal CIT uptake may have correlation with cognitive dysfunctions in patients with Parkinson’s disease.

References: [1]. Jin, S., Oh, M., Oh, S. J., Oh, J. S., Lee, S. J., Chung, S. J., . . . Kim, J. S. (2013). Differential Diagnosis of Parkinsonism Using Dual-Phase F-18 FP-CIT PET Imaging. Nucl Med Mol Imaging, 47(1), 44-51. [2]. Kasten, M., Bruggemann, N., Schmidt, A., & Klein, C. (2010). Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology, 75(5), 478; author reply 478-479.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/correlation-between-striatal-cit-uptake-and-mini-mental-state-examination-in-parkinsons-disease/