Objective: This report will describe the utilization and parameters associated with the use of a new visualization tool for Deep Brain Stimulation (DBS) programming in a subset of Parkinson’s disease (PD) subjects participating in the INTREPID Randomized Controlled Trial.

Background: Typically, optimization of DBS programming involves an ongoing, and sometimes lengthy or inefficient, trial-and-error process of various stimulation parameters that relies on clinician assessment and subject reporting of clinical benefit. The use of a new visualization tool that can illustrate the location of the DBS lead in the patient’s own-segmented anatomy may help to improve the efficiency of achieving programming optimization and outcomes specific to the individual patient (Pavese, S. et al. [Abstract]. 20th International Congress of the International Parkinson and Movement Disorders Society, 2016).

Method: INTREPID (ClinicalTrials.gov Identifier: NCT01839396) was a multi-center, prospective, double-blinded randomized controlled trial (RCT) sponsored by Boston Scientific. Subjects with advanced PD were implanted bilaterally in the STN with a multiple-source, constant current DBS System (Vercise, Boston Scientific). In the long-term follow-up phase of the study, a subset of subjects was assessed and programmed, as needed, using a newly available visualization tool (GUIDE XT, Boston Scientific).

Results: Data collection with use of the visualization tool, implemented in up to 30 subjects, is currently ongoing. Preliminary analysis suggests an improvement in motor function and better resolution of adverse effects. Detailed analysis of programming parameters correlated with volume of tissue activated will be presented. Additionally, any case reports of instances where the use of tool help fine tune their settings and associated impact on outcomes will also be presented.

Conclusion: Use of a visualization tool to help guide DBS programming, may offer an opportunity to enhance the overall experience of DBS, thereby potentially contributing to achieving highly effective and desired clinical outcomes.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/utilization-of-a-visualization-software-tool-for-deep-brain-stimulation-programming-in-a-subset-of-subjects-with-parkinsons-disease-who-participated-in-the-intrepid-randomized-clinical-trial/