Category: Parkinson's Disease: Neurophysiology
Objective: We aimed to record LFPs of the subthalamic nucleus (STN) from a PD patient with a new implantable pulse generator (IPG), which is capable of stimulation and simultaneous recording of local field potentials (LFPs) from the recording electrode (Medtronic PerceptTM).
Background: DBS has become the treatment of choice for advanced stages of PD. Adaptive closed-loop DBS aims to integrate LFPs and other neuronal and kinematic feedback signals to adjust the DBS signal to each individual patient’s needs in real time.
Method: To investigate if these peaks share the same or different physiological meanings, we studied the impact of increased stimulation strength as well as movement (gait) on their amplitudes. Further, burst characteristics of the low (13-20 Hz) and high beta band (20-30 Hz) were investigated. All recordings were in the medication-off state.
Results: The frequency spectra showed two peaks in the beta band (13 – 30 Hz) on each side both with external intra-operative equipment and implanted post-operative Percept, which is an uncommon result of such recordings. On the right side, both beta peaks were completely suppressed by clinically efficient stimulation and re-appeared immediately (within a second) after cessation of stimulation. On the left side, the two beta peaks at 15 and 25 Hz behaved similarly, but in the stimulation-on condition, a peak at 13 Hz appeared such that the ‘low-beta frequency band’ was nearly unaffected by stimulation. During movement (gait) high beta peaks were still preserved but fully suppressed by initiation of stimulation during walking, correlated with a clear improvement of gait performance parameters. Burst-timing in the low and high beta band showed little if any correlation.
Conclusion: The beta band oscillations may contain activity with different characteristics which must be regarded carefully when used as biomarkers for closed loop DBS. Gait did not fully suppress high beta activity in the medication off state. Being able to identify this during closed loop system setup may help to select the proper beta peak and insure the success of closed loop systems.
References: n.a.
To cite this abstract in AMA style:
T. Koeglsperger, J. Mehrkens, K. Bötzel. Bilateral double beta peaks in a PD patient with STN electrodes [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/bilateral-double-beta-peaks-in-a-pd-patient-with-stn-electrodes/. Accessed May 9, 2025.« Back to MDS Virtual Congress 2020
MDS Abstracts - https://www.mdsabstracts.org/abstract/bilateral-double-beta-peaks-in-a-pd-patient-with-stn-electrodes/