Objective: To study the level of glial neurotrophic disease in blood plasma in patients with Parkinson’s disease (PD) depending on the stage
Background: Parkinson’s disease (PD), along with other neurodegenerative diseases of the nervous system, is one of the most pressing socio-economic problems today and is one of the main causes of disability
Method: A total of 88 patients were screened to assess the role and importance of glial neurotrophic factor in the early detection of Parkinson’s disease. 78 patients with PD disease and 10 patients who did not have PC disease in the control group. Of the patients examined in the main group, 39 (50%) were men and 39 (50%) were women. Accordingly, the control group consisted of 5 men (50%) men and 5 women (50%). The average age of male patients with PC was 18-70 years, with an average age of 52.6 ± 11.1 years, and the average age of women was 32-68 years, with an average age of 59.7±10.9 years. The duration of the disease was 4.1 ± 5.6 years in men and 6.32 ± 5.8 years in women. GDNF levels were determined by enzyme immunoassay
Results: The results of measurements were obtained that in the blood serum of patients of the main group, the amount of glial neurotic inflammation was 34.655±7.5 pg/ml, in the control group 73.558±8.2 pg/ml, (p<0.05). In the next phase of the study, we found it necessary to perform a comparative analysis of serum GDNF in patients with various stage of PD. The results show that the amount of GDNF in the 1-stage is 26,3±4,9 pg / ml, in the 2-stage of the disease – 21,7±4,1 pg/ml, and in the 3-stage of the disease – 16,6±3,5 pg / ml , while in the early stages of the disease in 25 patients this figure was 38.2 ± 6.7 pg / ml.
Conclusion: The results obtained can be explained by the fact that the glial neurotrophic factor is specific to the astrocytic glia and is the main factor that nourishes the dopaminergic neurons.. Begins to decrease along the series of 1-stage, 2-stage and 3-stage.
To cite this abstract in AMA style:
R. Matmurodov, M. Muminov, A. Abduqodirov, K. Khalimova. The level of glial neurotrophic factor in blood plasma depending on the stage of Parkinson’s disease [abstract]. Mov Disord. 2022; 37 (suppl 2). https://www.mdsabstracts.org/abstract/the-level-of-glial-neurotrophic-factor-in-blood-plasma-depending-on-the-stage-of-parkinsons-disease/. Accessed May 9, 2025.« Back to 2022 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-level-of-glial-neurotrophic-factor-in-blood-plasma-depending-on-the-stage-of-parkinsons-disease/