2022 International Congress » Parkinson's Disease: Molecular Mechanisms of Disease

A longitudinal evaluation of the peripheral immune phenotype in a cohort of Parkinson’s disease patients

L. Magistrelli, A. Furgiuele, E. Contaldi, M. Legnaro, E. Rasini, C. Comi, F. Marino, M. Cosentino (Novara, Italy)

A mouse model to test the cortical pathogenic theory of Parkinson’s disease

M. Moreno-Gómez, D. Humanes-Valera, J. Pardo-Valencia, N. Mercado-García, B. Pro-Sánchez, A. Revuelto-González, T. Balzano, J. Blesa, A. Bortolozzi, J A. Obeso, G. Foffani (Móstoles, Spain)

A secretory vesicle failure in Parkinson’s disease occurs in human platelets

P. Montenegro, M. Pueyo, JN. Lorenzo, R. González-Brito, A. Méndez, R. Borges (La Laguna, Spain)

Alterations in neuron-derived exosomal cargo in Parkinson Disease

V. Gorgogietas, IB. Boussaad, F. Borgmann, M. Mittelbronn, R. Krueger (Esch-sur-Alzette, Luxembourg)

Analyzing the metabolic function of DJ-1 in the pathogenesis of Parkinson`s disease (PD) and Glioblastoma multiforme (GBM)

P. Mencke (Esch-sur-Alzette, Luxembourg)

Bis(monoacylglycerol) phosphate levels are elevated at baseline in carriers of pathogenic variants in LRRK2 and GBA1 and do not predict progression of PD in PPMI cohorts

K. Merchant, T. Simuni, J. Fedler, M. Brumm, C. Caspell, E. Tangstrandt, F. Hsieh, K. Nudelman, T. Foroud, C. Coffey, A. Siderowf, C. Tanner, K. Marek, P. Investigators (Chicago, USA)

Blood microRNA-7 as a Progression Biomarker in Parkinson’s disease

M. Doursout, C. Adams, J. Suescun, K. Block, E. Tharp, T. Ellmore, M. Schiess (Houston, USA)

Blood-derived α-synuclein from Parkinson´s disease patients is able to seed pathology

A. Kluge, J. Bunk, E. Schäffer, H. Knacke, A. Drobny, W. Xiang, R. Lucius, P. Arnold, F. Zunke, D. Berg (Kiel, Germany)

Brain glia activation and peripheral inflammation in Parkinson’s disease: a PET study

SY. Liu, HW. Qiao, TB. Song, O. Barret, FW. Qiao, XL. Liu, X. Xu, YN. Cai, G. Tamagnan, V. Sossi, P. Chan (Beijing, China)

Can membrane association of α-synuclein aggregates lead to stress in the astrocytic endoplasmic reticulum?

A. Raj, I. Datta, R. Banerjee (Bangalore, India)

Changes in the level of glial neurotrophic factor in Parkinson’s disease depending on the form

B. Muminov, R. Matmurodov, E. Abduqodirov (Tashkent, Uzbekistan)

Characterising Natural Killer cells in early Parkinson’s disease

J. Holbrook, B. Patel, M. Camacho, C. Williams-Gray (Cambridge, United Kingdom)

Differential proteomic analysis of plasma exosomes in Parkinson disease associated with mutations in the GBA gene

T. Usenko, A. Bezrukova, K. Basharova, D. Kulabukhova, I. Miliukhina, E. Zakharova, S. Naryzhny, S. Pchelina (Gatchina, Russian Federation)

DNMT1 level and global DNA methylation in CD45+ blood cells in Parkinson’s disease

A. Lavrinova, A. Zhuravlev, I. Miliukhina, E. Belykh, A. Tyurin, O. Berkovich, S. Pchelina, A. Emelyanov (Gatchina, Russian Federation)

Dopamine neuron platform for screening molecular mechanisms and inhibitory drugs against alpha-synuclein aggregation

S. Er, I. Hlushchuk, P. Chmielarz, A. Domanskyi, M. Airavaara (Helsinki, Finland)

Early Synucleinopathy is Associated with Differential Regulation of Neurotransmission and Immune Related Genes

J. Patterson, J. Kochmanski, A. Stoll, M. Kubik, C. Kemp, J. Howe, M. Duffy, K. Miller, A. Cole-Strauss, J. Beck, S. Counts, K. Steece-Collier, A. Bernstein, K. Luk, C. Sortwell (Grand Rapids, USA)

Evaluation of ocular perfusion in Parkinson’s disease and association with clinical manifestations.

A. Camacho-Ordonez, M. Rodriguez-Violante, A. Cervantes-Arriaga, A. Hernández-Medrano, O. Guerrero-Berger (Mexico, Mexico)

Evaluation of α-synuclein pathology and function in dopaminergic neurons derived from LRRK2 I1371V PD patient iPSCs

I. Datta, S. Jagtap, C. Potdar (Bangalore, India)

Exenatide protects iPSC-derived dopaminergic neurons with A53T mutation through restoration of insulin signaling

D. Athauda, J. Evans, A. Wernick, G. Virdi, M. Choi, K. D'Sa, Z. Shadman, N. Greig, T. Foltynie, S. Gandhi (London, United Kingdom)

Fibrinogen and CFAH: The two putative markers of Parkinson’s disease with cognitive impairment

A. Naskar, S. M, S. Sengupta, P. Pal, P. Alladi (Bengaluru, India)

Glial neurotrophic factor as an early diagnostic marker in Parkinson’s disease

M. Matmurodov, A. Abduqodirov, L. Khalimova, B. Muminov (Tashkent, Uzbekistan)

Impact of Th17 pathway-related immuno-inflammatory cytokines in the risk and severity of Parkinson’s Disease.

M. Debnath, M. Gothwal, N. Sreenivas, S. Dey, M. Thrinath, R. Yadav, PK. Pal, J. Saini (Bengaluru, India)

Increased alpha-synuclein level in primary macrophages derived from patients with Parkinson’s disease

A. Kopytova, M. Nikolaev, G. Baydakova, A. Izymchenko, D. Bogdanova, I. Miliukhina, A. Emelyanov, E. Zakharova, S. Pchelina (Gatchina, Russian Federation)

Inflammatory microglial and astroglial phenotype associated with pathological alpha-synuclein inclusions in the substantia nigra

A. Stoll, M. Bensky, J. Patterson, C. Kemp, K. Steece-Collier, M. Hore, K. Luk, C. Sortwell (Grand Rapids, USA)

Investigating inflammatory mechanisms in iPSC-derived LRRK2 microglia

K. Badanjak, P. Mulica, P. Seibler, M. Ali, C. Venegas, S. Pereira, C. Klein, P. Antony, E. Glaab, A. Grünewald (Esch-Sur-Alzette, Luxembourg)

Lack of Toll-like receptor 4 is associated with accumulation of alpha-synuclein in the midbrain Parkinson’s disease mice.

C. Conte, G. Mariucci, R. Cafaro (Perugia, Italy)

Level of glial neurotrophic factor in the blood plasma depending on the duration of Parkinson’s disease

B. Muminov, R. Matmurodov, E. Abduqodirov (Tashkent, Uzbekistan)

Long non-coding RNAs in Parkinson’s disease: bringing back life to the grey matter?

S. Acharya, A. Lumley, L. Zhang, V. Stopa, Y. Devaux (Strassen, Luxembourg)

miR-218-5p Regulates Microglia-mediated Neuroinflammation through Type I Interferon Response in Parkinson’s Disease

D. Wang, Q. Qin, J. Li, J. Zhao, Z. Mao, Z. Xue (Wuhan, China)

Multi-modal prognostic biomarkers for Parkinson’s disease progression and severity

AS. Rolland, M. Dutheil, O. Simonin, R. Viard, V. Huin, M. Kyheng, C. Moreau, S. Thobois, A. Eusebio, E. Hainque, I. Benatru, D. Maltete, C. Giordana, M. Tir, C. Hubsch, B. Jarraya, F. Durif, C. Brefel-Courbon, O. Rascol, JC. Corvol, G. Garçon, D. Devos (Lille, France)

Mutational effects of LRRK2 I1371V in astrocytes derived from patient specific iPSCs

R. Banerjee, I. Datta, S. Jagtap, A. Raj (Bangalore, India)

Oligomeric alpha-synuclein in reflex tears and retinal changes in Parkinson’s disease

A. Camacho-Ordonez, M. Rodriguez-Violante, A. Cervantes-Arriaga, A. Hernández-Medrano, S. Somilleda-Ventura, H. Perez-Cano, O. Guerrero-Berger (Mexico, Mexico)

Parkin deficiency impairs mtDNA dynamics and propagates inflammation

K. Wasner, S. Smajić, J. Ghelfi, S. Delcambre, C. Prada-Medina, E. Knappe, G. Arena, P. Mulica, G. Agyeah, A. Rakovic, I. Boussaad, K. Badanjak, J. Ohnmacht, J. Gérardy, M. Takanashi, J. Trinh, M. Mittelbronn, N. Hattori, C. Klein, P. Antony, P. Seibler, M. Spielmann, S. Pereira, A. Grünewald (Belvaux, Luxembourg)

Patterns of TDP-43 Deposition in Brains with LRRK2 G2019S Mutations

J. Agin-Liebes, R. Hickman, J. Vonsattel, X. Flowers, P. Faust, R. Mayeux, K. Marder, S. Przedborski, S. Fahn, M. Surface, R. Alcalay (New York, USA)

Presynaptic dopamine compartmentalization defects initiate auxilin-mediated parkinsonism

D J. Vidyadhara, M. Somayaji, N. Wade, H. Zhao, S. Narayanan, J. Gupta, T. Lam, D. Sames, L. Greene, D. Sulzer, S. Chandra (New Haven, USA)

Profiling the biochemical lysosomal activities in blood of patients with LRRK2 G2019S associated Parkinson’s disease

K. Basharova, A. Bezrukova, I. Miliukhina, A. Timofeeva, E. Zakharova, S. Pchelina, T. Usenko (Gatchina, Russian Federation)

Protective mechanism of melatonin via heat shock protein in the MPP+-induced in vitro Parkinson’s disease model

YJ. Jung, E. Oh, A. Kim, H. Choi (Daejeon, Republic of Korea)

Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in enriched iPSC-derived human midbrain dopaminergic neurons

G. Virdi, M. Choi, J. Evans, S. Strohbuecker, M. Horrocks, R. Patani, S. Gandhi (London, United Kingdom)

Single-cell characterization of patient midbrain tissue reveals tissue remodeling and glial activation in Parkinson’s disease

S. Smajic, C. Prada-Medina, Z. Landoulsi, J. Ghelfi, S. Delcambre, C. Dietrich, J. Jarazo, J. Henck, S. Balachandran, S. Pachchek, C. Morris, P. Anotny, B. Timmermann, S. Sauer, S. Pereira, J. Schwamborn, P. May, M. Spielmann (Esch-sur-Alzette, Luxembourg)

The level of glial neurotrophic factor in blood plasma depending on the stage of Parkinson’s disease

R. Matmurodov, M. Muminov, A. Abduqodirov, K. Khalimova (Tashkent, Uzbekistan)

The overexpression of a-SYN leads to a differential process of mitophagy in neurons and atrocytes

I. Lastres-Becker, S. Castro-Sánchez, I. Silva-Llanes, P. Teresak, JL. Lanciego, E. Sierra, P. Boya (Madrid, Spain)

The role of GBA1 mutations in the relationship between GBA1 and alpha-synuclein in Parkinson disease

L. Smith, M. Gegg, D. Chau, AHV. Schapira (London, United Kingdom)

The Vall d’Hebron Initiative for Parkinson (VHIP) cohort: a prospective, longitudinal and observational study enrolling de novo Parkinson’s disease (PD) patients and carriers of PD-linked mutations for biomarker and pathophysiology studies

D. Samaniego-Toro, L. Domingo-Rodriguez, M. Camprodon-Gómez, M. Armengol-Bellapart, V. González, S. Lucas-Del-Pozo, E. Xicoy, J. Riera-Heredia, D. Montpeyó, M. Martinez-Vicente, A. Laguna, J. Hernandez-Vara (Barcelona, Spain)

Type 2 diabetes-associated transcriptomic changes in Parkinson’s disease and non-neurodegenerative control brains.

P. Cullinane, E. de Pablo-Fernandez, K. Ebanks, Z. Jaunmuktane, T. Warner (London, United Kingdom)

Utility of Seed Amplification Assay for Detecting α-synuclein in Formalin-Fixed Paraffin Embedded Skin Samples in Parkinson’s Disease

S. Mosovsky, M. Hepker, A. Kanthasamy, S. Pritzkow, M. Pinho, C. Adler, T. Beach, T. Foroud, G. Serrano, J. Eberling, L. Oliveira, S. Appel, B. Mollenhauer, L. Chahine (Pittsburgh, USA)