Objective: To analyse hippocampal volume differences among the patients with Parkinson’s disease and healthy individuals.

Background: In humans, hippocampus is involved in regulation of emotions, memory, learning and understanding processes. MRI imaging studies have revealed that hippocampal volume may vary between the demented and non-demented/ healthy individuals. Parkinson’s disease has associated mild cognitive impairment which can start early in the disease.

Method: Hippocampal volumes were calculated for non demented PD patients (90) and 25 age, gender matched healthy controls using 3T – Magnetic Resonance Imaging (2D gradient-echo sequencing, T2, axial, continuous, 2mm thickness, no interleaving slices) on Singovia workstation. ROC analysis was done for sensitivity and specificity.

Results: In our study Hippocampal volume in PD patients was significantly lower than controls.  Based on Youden’s index (Maximum = Sensitivity +Specificity – 1) the cut-off value for right hippocampal volume was165.22 and at this cut-off value sensitivity was 82.22% and specificity was 84%. The cut-off value for left hippocampal volume was 154.56 and at this value the sensitivity was 75.56% and specificity was 80%. Similarly, the cut-off value for average hippocampal volume was 161.19, and at this value the sensitivity was 74.19% and specificity was 84%.

Conclusion: Our study suggests that hippocampal volume is reduced in PD patients and may be a probable image marker for Parkinson’s disease.

ROC curve for L hippocampus volume

ROC curve for right hippocampal volume

ROC curve for hippocampal volume

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MDS Abstracts - https://www.mdsabstracts.org/abstract/hippocampal-volume-in-parkinsons-disease-in-south-india/