Category: Parkinson's Disease: Neuroimaging
Objective: To analyse hippocampal volume differences among the patients with Parkinson’s disease and healthy individuals.
Background: In humans, hippocampus is involved in regulation of emotions, memory, learning and understanding processes. MRI imaging studies have revealed that hippocampal volume may vary between the demented and non-demented/ healthy individuals. Parkinson’s disease has associated mild cognitive impairment which can start early in the disease.
Method: Hippocampal volumes were calculated for non demented PD patients (90) and 25 age, gender matched healthy controls using 3T – Magnetic Resonance Imaging (2D gradient-echo sequencing, T2, axial, continuous, 2mm thickness, no interleaving slices) on Singovia workstation. ROC analysis was done for sensitivity and specificity.
Results: In our study Hippocampal volume in PD patients was significantly lower than controls. Based on Youden’s index (Maximum = Sensitivity +Specificity – 1) the cut-off value for right hippocampal volume was165.22 and at this cut-off value sensitivity was 82.22% and specificity was 84%. The cut-off value for left hippocampal volume was 154.56 and at this value the sensitivity was 75.56% and specificity was 80%. Similarly, the cut-off value for average hippocampal volume was 161.19, and at this value the sensitivity was 74.19% and specificity was 84%.
Conclusion: Our study suggests that hippocampal volume is reduced in PD patients and may be a probable image marker for Parkinson’s disease.
To cite this abstract in AMA style:
R. Kandadai, T. Syed, A. Arora, T. Sd, S. Kola, S. Yaranagula, V. Prasad, R. Alugolu, S. Turaga, R. Borgohain. Hippocampal volume in Parkinson’s Disease in south India [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/hippocampal-volume-in-parkinsons-disease-in-south-india/. Accessed October 5, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/hippocampal-volume-in-parkinsons-disease-in-south-india/