Category: Parkinson's Disease: Non-Motor Symptoms
Objective: To compare the 60-months quality of life (QoL) effects of subthalamic stimulation (STN-DBS) to standard-of-care oral/transdermal medical therapy (MED) in Parkinson’s disease (PD).
Background: Little is known about long-term outcomes of STN-DBS on QoL in PD.
Method: Here, we report the 60-month follow-up of a prospective, observational, controlled, international multicenter study. Assessments included PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD (SCOPA)‑motor examination, ‑activities of daily living (ADL), and ‑complications, and levodopa-equivalent daily dose (LEDD). Propensity score matching identified a sub-cohort with balanced baseline characteristics between the STN-DBS and MED groups. We analyzed within-group longitudinal outcome changes using Wilcoxon signed-rank and between-group differences of change scores using Mann-Whitney U tests.
Results: Propensity score matching applied on 106 patients (STN-DBS n=60, MED n=46) resulted in a well-balanced sub-cohort including 25 patients per group. STN-DBS outcomes were favorable for motor complications and LEDD reduction. PDQ-8 and ADL worsened in the MED group only. Changes of PDQ-8 and ADL correlated.
Conclusion: This study provides Class IIb evidence that long-term STN-DBS resulted in stable QoL outcome. In the MED group, QoL worsened and this impairment was associated with worsened ADL outcomes at 60-month follow-up. This study highlights the importance of ADL for long-term QoL outcomes of surgical and conventional medical therapy of PD.
To cite this abstract in AMA style:
S. Jost, S. Aloui, A. Rizos, K. Ashkan, J. Evans, A. Sauerbier, J. Petry-Schmelzer, A. Gronostay, G. Fink, M. Barbe, V. Visser-Vandewalle, A. Antonini, M. Silverdale, P. Martinez-Martin, L. Timmermann, K. Ray Chaudhuri, H. Dafsari. A prospective, controlled study of subthalamic stimulation in Parkinson’s disease: quality of life outcome at the 5-year follow-up [abstract]. Mov Disord. 2022; 37 (suppl 2). https://www.mdsabstracts.org/abstract/a-prospective-controlled-study-of-subthalamic-stimulation-in-parkinsons-disease-quality-of-life-outcome-at-the-5-year-follow-up/. Accessed November 3, 2024.« Back to 2022 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/a-prospective-controlled-study-of-subthalamic-stimulation-in-parkinsons-disease-quality-of-life-outcome-at-the-5-year-follow-up/