Objective: The objective of the present investigation was to develop Mucoadhesive sustained release floating tablets of Silymarin using natural polymers (Coccinia grandis and Rumex vasicarious) and evaluate various physicochemical properties and in -vivo anti Parkinson activity in retonone induced mice model

Background: Silymarin is a standardized seed extract and acts as antioxidants. The short half life, poor bioavailability and faster solubility in acidic media make it a suitable candidate for development of Mucoadhesive sustained release floating tablets of Silymarin [1]. These developed formulations were exhibited improved stability of the drug in the stomach the anti –Parkinson activity.

Method: Mucoadhesive sustained release floating tablets of Silymarin was developed my direct compression technique using Coccinia grandis and Rumex vasicarious natural polymers and subjected to evaluation of dimensions of a tablet, Density of a tablet, Friability test, Tablet weight variation, Drug content uniformity, In vitro buoyancy study, Swelling Studies (Swelling Index), FTIR, DSC, XRD, In vitro drug release studies, Kinetic modeling of drug release profile [2]. Furthermore, the optimized tablets were subjected to evaluation of In -vivo anti Parkinson activity in the retonone induced mice model.

Results: Silymarin loaded floating tablets were developed by using various concentrations of Coccinia grandis and Rumex vasicarious natural polymers alone and the combination with synthetic polymers successfully. The results of dimensions of a tablet, Density of a tablet, Friability test, Tablet weight variation, Drug content uniformity, In vitro buoyancy study, Swelling Studies (Swelling Index), FTIR, DSC, and XRD were exhibited the satisfactory and as per the pharmacopeia limits. The In-vitro drug release profile of the developed tablets was exhibited up to 12 hrs. Additionally, the developed tablets were shown superior In-vivo anti Parkinson activity as compared to marketed formulations.

Conclusion: The Mucoadhesive sustained release floating tablets of Silyamrin developed with Coccinia grandis and Rumex vasicarious are novel, low cost, patient friendly systems and they were exhibited superior anti-Parkinson activity as compared to marketed formulation.

References: 1. Ullah H and Khan H, Anti-Parkinson Potential of Silymarin: Mechanistic Insight and Therapeutic Standing, Pharmacol, 9: 422; 2018. 2. Garg R and Gupta GD, Preparation and evaluation of gastroretentive floating tablets of Silymarin. Chem Pharm Bull, 57(6):545-9; 2009. Acknowledgement: The authors are thankful to SERB-DST Govt of India for funding this research work.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/development-of-mucoadhesive-sustained-release-floating-tablets-of-silymarin-using-natural-polymer-for-improved-anti-parkinson-efficacy/