Objective: The aim of this prospective study is to compare the effects of GPi and STN stimulation in PD patients on neuropsychiatric disorders and quality of life. 

Background: Deep brain stimulation (DBS) of either, the internal globus pallidus (GPi) and the subthalamic nucleus (STN), has been reported to improve the motor symptoms of Parkinson’s disease (PD). However, different targets may present different post operative effects on cognitive and neuropsychiatric symptoms. 

Methods: Bilateral deep brain stimulation was implanted in the GPi in 13/26 patients and in the STN in 13/26 patients. Quality of life, neuropsychiatric symptoms, screening for global cognition, screening for dementia were assessed using scales and standardized tests at the baseline and 6 months after surgery.

Results: There was no significant difference in the tests that assessed cognitive function in both groups. However, there was a significant improvement in neuropsychiatric symptoms and quality of life (total score, p= 0,002) in the PD group with GPi-DBS. 

Conclusions: In this series, stimulation DBS did not affect the cognitive performance, relieved significantly neuropsychiatric symptoms and quality of life in PD GPi-DBS. 

References: Ciampi DA, Lefaucheur JP, Galhardoni R, et al. Subthalamic deep brain stimulation modulates small fiber-dependent sensory thresholds in Parkinson’s disease. Pain.2012 May; 153-69.

Voon V, Kudu C, Krack P, Houeto JL, Tröster AI. Deep brain stimulation: neuropsychological and neuropsychiatric issues. Mov. Disord. 2006 Jun; 21 (S14): S305-27.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/neuropsychiatric-symptoms-after-bilateral-stimulation-in-parkinsons-disease-subthalamic-nucleus-versus-globus-pallidus-internus/