Objective: To explore novelty seeking (NS) as a construct, in both its adaptive and maladaptive roles, in order to provide insight into the cognitive and behavioral changes that occur in Parkinson’s Disease (PD) and inspire new avenues for diagnostic or therapeutic intervention in these patients.
Background: PD is a complex neurodegenerative condition characterized not only by motor disability but also by cognitive and affective changes. The “Parkinson’s personality” is sometimes utilized to describe patients’ premorbid traits of inflexibility, orderliness, introversion, cautiousness, and punctuality. Though there is little agreement on a unified description of PD personality, novelty-seeking (NS) has emerged as a biologically-relevant trait. NS represents a dimension of temperament which increases exploratory behavior when stimuli are new or different.
Method: A narrative review of all the relevant papers known to the author was conducted, applying Cloninger’s Tridimensional Personality Questionnaire to determine potential for tailored therapies in PD.
Results: Cloninger’s model of personality was based on heritable differences in monoamine neurotransmitter receptor polymorphisms and inspired rat models which continue to demonstrate construct validity in the study of human NS traits as evidenced by the recent applications of a human Behavioral Pattern Monitor. NS is generally low in early disease and increases with advancing disease and increasing dopaminergic therapy. NS has significant associations with addiction and impulse control disorders (ICDs) and intersects with several other neuropsychiatric conditions. New treatments for ICDs have failed to enter routine clinical practice, but psychedelics are now being studied in addiction with some promising results. The recent identification of the zona incerta as a unique driver of NS, independent of reward, also implicates deep brain stimulation in the treatment of ICD
Conclusion: As a dynamic feature of the “Parkinson’s personality,” influenced both by disease state and medications, NS offers a unique window into the study of PD patients and has an adaptive role beyond its associations with impulsivity.
References: 1 Ishihara, Lianna, and Carol Brayne. “What is the evidence for a premorbid parkinsonian personality: a systematic review.” Movement disorders: official journal of the Movement Disorder Society 21.8 (2006): 1066-1072.
2 Santangelo G, et. al. Personality and Parkinson’s disease: A meta-analysis. Parkinsonism Relat Disord. 2018 Apr;49:67-74.
3 Menza M. The personality associated with Parkinson’s disease. Curr Psychiatry Rep. 2000 Oct;2(5):421-6
4 Cloninger CR. A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatr Dev. 1986 Autumn;4(3):167-226.
5 Boussac M, et. al. PREDI-STIM study group. Personality dimensions of patients can change during the course of parkinson’s disease. PLoS One. 2021 Jan 7;16(1).
6 Bódi N, Kéri S, Nagy H, Moustafa A, Myers CE, Daw N, Dibó G, Takáts A, Bereczki D, Gluck MA. Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson’s patients. Brain. 2009 Sep;132(Pt 9):2385-95.
7 Mathieu M. Blanchard, Daniel Mendelsohn, Jennifer A. Stamp. The HR/LR model: Further evidence as an animal model of sensation seeking, Neuroscience & Biobehavioral Reviews, Volume 33, Issue 7,2009, Pages 1145-1154.
8 Arpi Minassian, John R. Kelsoe, Alannah Miranda, Jared W. Young, William Perry, The relationship between novelty-seeking traits and behavior: Establishing construct validity for the human Behavioral Pattern Monitor, Psychiatry Research,Volume 316, 2022, 114776.
9 Andrew Jaegle, Vahid Mehrpour, Nicole Rust; Visual novelty, curiosity, and intrinsic reward in machine learning and the brain, Current Opinion in Neurobiology, Volume 58, 2019, Pages 167-174.
10 Ogasawara, T., Sogukpinar, F., Zhang, K. et al. A primate temporal cortex–zona incerta pathway for novelty seeking. Nat Neurosci 25, 50–60 (2022).
11 Stephen M. Strakowski, Andrew L. Stoll, Mauricio Tohen, Gianni L. Faedda, Daniel C. Goodwin, The tridimensional personality questionnaire as a predictor of six-month outcome in first episode mania, Psychiatry Research, Volume 48, Issue 1, 1993, Pages 1-8.
12 Semnani Y., Kheradman dA.. (2019) Temperament and Character Traits in Bipolar “I” Inpatients with and without Substance Abuse. Open Science Journal 4 (1).
13 Peritogiannis V. Sensation/novelty seeking in psychotic disorders: A review of the literature. World J Psychiatry. 2015 Mar 22;5(1):79-87. doi: 10.5498/wjp.v5.i1.79..
14 Wingo T, Nesil T, Choi JS, Li MD. Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules. J Neuroimmune Pharmacol. 2016 Sep;11(3):456-70.
15 Gemma Modinos, et. al. Neural Circuitry of Novelty Salience Processing in Psychosis Risk: Association With Clinical Outcome, Schizophrenia Bulletin, Volume 46, Issue 3, May 2020, Pages 670–679, 6
16 Henrik Anckarsäter M.D., Ph.D., et al. The Impact of ADHD and Autism Spectrum Disorders on Temperament, Character, and Personality Development. Am J Psychiatry 2006; 163:1239–1244.
17 Kimberly Papay, Sharon X. Xie, Matthew Stern, Howard Hurtig, Andrew Siderowf, John E. Duda, James Minger, Daniel Weintraub. Naltrexone for impulse control disorders in Parkinson disease: A placebo-controlled study. Neurology Aug 2014, 83 (9) 826-833
18 Mestre TA, Strafella AP, Thomsen T, Voon V, Miyasaki J. Diagnosis and treatment of impulse control disorders in patients with movement disorders. Ther Adv Neurol Disord. 2013 May;6 (3):175-88.
19 Bruno Romeo, Marianne Hermand, Amélie Pétillion, Laurent Karila, Amine Benyamina, Clinical and biological predictors of psychedelic response in the treatment of psychiatric and addictive disorders: A systematic review, Journal of Psychiatric Research, Volume 137, 2021, Pages 273-282.
20 R.L. Carhart-Harris, D.J. Nutt. Serotonin and brain function: a tale of two receptors. J. Psychopharmacol., 31 (2017), pp. 1091-1120
21 Li WW, Yu H, Miller DJ, Yang F, Rouen C. Novelty Seeking and Mental Health in Chinese University Students Before, During, and After the COVID-19 Pandemic Lockdown: A Longitudinal Study. Front Psychol. 2020 Dec 3.
To cite this abstract in AMA style:K. Paulk, L. Neilson. Novelty Seeking: A Narrative Review [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/novelty-seeking-a-narrative-review/. Accessed September 22, 2023.
« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/novelty-seeking-a-narrative-review/