Decoding Parkinson’s Disease Metabolic Landscape: Targeted 4D-Metabolomics of Urinary Amine-Phenol Submetabolomes for Specific Signature Identification and Biomarker Discovery
Objective: To develop a non-invasive diagnostic strategy for Parkinson’s disease (PD) via targeted 4D-metabolomics, identify PD-specific urinary amine-phenol biomarkers, and explore PD-related metabolic mechanisms. Background:…Clinical Utility of Neurophysiological Tremor Study Within a Joint Neurology-Neurophysiology Movement Disorders Clinic: One-Year Retrospective Two-Center Study
Objective: To assess concordance between initial clinical diagnosis and neurophysiological tremor study-based diagnosis, combining surface EMG and accelerometry, and to explore the diagnostic utility of…Traumatic Brain Injury Exacerbates Parkinsonian Neurodegeneration Through Alpha Synuclein Dysregulation
Objective: This study aimed to determine whether repetitive mild traumatic brain injury exacerbates Parkinsonian neurodegeneration and promotes alpha synuclein pathology in an experimental model. Background:…Iron Dysregulation and Metabolic Inflammation in Restless Legs Syndrome: Clinical Correlates from a Tertiary hospital Cohort
Objective: To evaluate clinical characteristics, iron status, and metabolic comorbidities in patients with Restless Legs Syndrome (RLS) and examine associations between peripheral iron parameters and…Cervical Dystonia: The Objective Evaluation Of Muscle Tone
Objective: In this study, we aimed to assess the biomechanical components underlying the postural alterations characteristic of CD. In addition, we investigated the effects of…Bidirectional Association Between Gout and Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To evaluate whether gout influences the risk of Parkinson’s disease (PD) and whether PD influences the subsequent risk of gout. Background: Gout and PD…Clinical Features and Trajectories Related to Entacapone Use in Parkinson’s Disease: insights from the French NS Park Cohort
Objective: This study aimed to provide real-life entacapone use in French PD expert centers, focusing on temporal trends, therapeutic positioning, and treatment persistence. Background: Optimizing…Telemedicine in Parkinson’s Disease Management: Lessons from Resource-Limited Settings Like Nepal
Objective: To evaluate the feasibility, clinical outcomes, and patient satisfaction of telemedicine-based Parkinson’s disease management in Nepal. Background: Parkinson’s disease (PD) is a chronic neurodegenerative…Nutritional Assessment in X-linked Dystonia Parkinsonism: Preliminary Results from a Pilot Study
Objective: This pilot study aims to evaluate the nutritional status of XDP patients using anthropometric measurements and nutritional assessment tools, and to determine the prevalence…Correlational Study of the Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD) with Functional Mobility Measures
Objective: To evaluate the correlation between CISI-PD by examining its association with four widely-validated functional mobility measures in PD: the 5 Times Sit-to-Stand Test (5xSTS),…
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