Focused Ultrasound for Essential Tremor: Results After One Year
Objective: Assessing the medium-term results following unilateral focused ultrasound ablation of the ventral intermediate nucleus of the thalamus in essential tremor. Background: Essential Tremor (ET)…Tongue Fasciculations in Amyotrophic Lateral Sclerosis Compared Between Electromyography and Transoral Ultrasonography
Objective: To compare the detection of tongue fasciculations between electromyography (EMG) and transoral motion-mode ultrasonography (TOMU) in patients with amyotrophic lateral sclerosis (ALS), and to…Integrating Transcriptomics and Morphological Profiling to Characterize GBA-Associated Parkinson’s Disease in Midbrain Organoids
Objective: This study characterizes converging biological trends in GBA-associated Parkinson’s Disease by integrating transcriptomic profiling with exploratory image-based analysis of donor-matched midbrain organoids. Background: High-content…Probabilistic Mapping of Subthalamic Beta and Theta Subcircuits Reveals Segregated Connectivity and Deep Brain Stimulation Outcomes in Parkinson’s Disease
Objective: To map theta- and beta-band activity within the subthalamic nucleus (STN) and examine associations with motor improvement and impulsive behavior in Parkinson’s disease (PD)…Correlational Study of the Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD) with Functional Mobility Measures
Objective: To evaluate the correlation between CISI-PD by examining its association with four widely-validated functional mobility measures in PD: the 5 Times Sit-to-Stand Test (5xSTS),…One day accelerated 10 Hz rTMS for Focal Hand Dystonia: A Phase II Clinical Trial
Objective: To evaluate the efficacy of four sessions of 10 Hz repetitive transcranial magnetic stimulation delivered in one day (rTMS) to patients with focal hand…Anti-IgLON5 Encephalitis Presenting as Chronic Progressive Asymmetrical Ataxia and Chorea
Objective: To report a case of gait instability and progressive asymmetrical chorea clinically confirmed as anti-IgLON5 encephalitis. Background: Anti-IgLON5 encephalitis is a rare autoimmune neurological…Bridging the Genomic Gap: Ancestry-Aware Polygenic Risk and Variant Discovery in African Parkinson’s Disease Cohorts
Objective: This study evaluates the shift from Euro-centric data to a diversified landscape. We aim to quantify the performance of European-derived Polygenic Risk Scores (PRS)…Clinical Effectiveness of Radiofrequency Thermal Ablative Lesioning for the Management of Motor Symptoms in Movement Disorders: Real-World Evidence
Objective: To further understand outcomes following radiofrequency (RF) thermal lesioning in the CNS, we conducted a real-world observational evaluation of patients who chose this therapy…A Longitudinal Case of Adult-Onset Progressive Ataxia in a Patient with a Pathogenic Variant of IRF2BPL
Objective: To describe the course of a patient with an inherited IRF2BPL variant presenting as adult-onset indolent ataxia and tremor with no prior developmental abnormalities,…
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