Tumor Pathology in Patients with Huntington’s Disease in a Specialized Center of Buenos Aires, Argentina (Preliminary Data)
Objective: To analyze the prevalence and type of neoplasms in patients with HD and to contrast it with the data of the general population in…Correlation between structural neuroimaging and clinical outcomes in a small sample of patients with early Huntington’s disease
Objective: Scores on the symbol digit modalities test (SDMT), Stroop word-reading, Total Motor Score (TMS) and composite UHDRS (cUHDRS) are correlated with disease progression and…Translating Preclinical Data to a Human Equivalent Dose for AMT-130 AAV Gene Therapy for Early Manifest Huntington’s Disease
Objective: To extrapolate the human equivalent dose (HED) for a Phase I/II clinical trial in adults to explore the safety, tolerability, and efficacy of striatally-administered…Cerebellar Ataxia in Patients with Huntington’s Disease, an underestimated symptom?
Objective: To analyze the prevalence of cerebellar ataxia in patients with Huntington’s Disease (HD), both early and late on HD progression and correlating the degree…Homozygous Huntington’s disease with two reduced penetrance alleles: A Case Report
Objective: To clinically characterize a Huntington's disease patient with two reduced penetrance alleles. Background: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder manifesting with…Insomnia as clinical onset symptom in Juvenile Huntington’s Disease: Evaluation of a Family
Objective: The aim of this study to emphasize that three juvenile form of HD cases who have insomnia as clinical onset symptoms. Background: Huntington’s Disease…MRI, Clinical, and Neuropathological Findings after Bilateral Intra-striatal Administration of rAAV5-miHTT in Non-human Primates
Objective: To assess the effects of intra-striatal administration of a huntingtin protein (HTT) lowering gene therapy in macaca fascicularis non-human primates (NHP). Background: The aggregation…The Roche HD Natural History Study – an external comparator by design
Objective: The Roche Natural History (NH) study in Huntington’s disease (HD) (NCT03664804) is a prospective, longitudinal cohort study designed to provide further clinical validation of…Assessment of Gait in Huntington’s disease patients using EncephaLog smartphone’s application
Objective: Huntington’s disease (HD) patients cope with unique gait disturbances. Proper evaluation of gait in these patients is highly needed. Dyskinesia may negatively affect validity…Comorbidities and medications in Huntington’s disease, Parkinson’s disease and the general population in a US claims database
Objective: This study characterises the comorbidities and symptoms, and treatment patterns of patients with Huntington’s disease (HD) vs patients with Parkinson’s disease (PD) vs the…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.