Impaired lysosomal catabolism of alpha-synuclein in parkinsonian LRRK2(R1441G) mutant mouse embryonic fibroblasts
Objective: Using a unique fluorescence-based flow cytometry assay on LRRK2(R1441G) mutant mouse embryonic fibroblasts (MEFs) to elucidate whether pathogenic LRRK2 mutation affects cellular lysosomal degradation…Drug Utilization in a Real World Cohort with Progressive Supranuclear Palsy
Objective: To evaluate the frequency of prescription medications commonly associated with the management of PSP in the community. Background: Progressive Supranuclear Palsy (PSP) is a…NEUROPSYCHIATRIC SYMPTOMS IN EARLY TO ADVANCED PATIENTS WITH THE RICHARDSON’S SYNDROME VARIANT OF PROGRESIVE SUPRANUCLEAR PALSY
Objective: To know prevalence of neuropsychiatric symptoms in Progressive Supranuclear Palsy along disease stages. Background: Neuropsychiatric symptoms are common features in patients with Progressive Supranuclear Palsy…Motor Responses to Apomorphine Sublingual Film Compared With Levodopa in Patients With Parkinson’s Disease and “OFF” Episodes: Post Hoc Analysis From a Phase 3 Study
Objective: To compare time to onset and magnitude of motor improvement following administration of apomorphine sublingual film (APL-130277; APL) vs levodopa in patients with Parkinson’s…Metabolic syndrome and insulin resistance in Parkinson’s disease: could they affect motor or cognitive symptoms?
Objective: The objective of this work was to detect the markers of metabolic syndrome and insulin resistance in patients with PD and to study their…Towards unobtrusive Parkinson’s disease detection via motor symptoms severity inference from multimodal smartphone-sensor data
Objective: To provide clinically-corroborated evidence of the Parkinson’s disease (PD) diagnostic potential of machine learning-based approaches for motor symptoms severity inference via multimodal data, passively…Accuracy of preoperative microelectrode trajectory planning in patients treated with DBS – an ongoing study
Objective: To retrospectively analyze the accuracy of the preoperative Deep Brain Stimulation (DBS) trajectory planning based on final trajectories chosen with intraoperative neurophysiological testing and…Parkinson’s disease polygenic risk score is not associated with impulse control disorders: a longitudinal study
Objective: To examine the relationship between a polygenic risk score (GRS) associated with Parkinson’s disease (PD) and impulse control disorders (ICDs) in PD. Background: Genome…Skin in the game: Small fiber neuropathy in Parkinson’s disease and atypical parkinsonisms.
Objective: The aim of our study was to compare somatic and autonomic small fiber density, through skin biopsy, in Parkinson's disease (PD) and atypical parkinsonisms…Impact of OFF periods on aspects of employment for people with Parkinson’s disease
Objective: To characterize the impact of OFF periods on aspects of employment for people with Parkinson’s disease (PD) who have OFF periods compared to those…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.