Novel COMT inhibitor opicapone shows sustained inhibition and improved L-DOPA availability in monkeys
Objective: To evaluate the effect of repeated OPC treatments, COMT inhibition versus plasma opicapone level, dose response of COMT inhibition, and systematic and central bioavailability…Association analysis of the nutritional status and serum nutritional index in patients with Parkinson’s disease
Objective: This study was conducted to determine the associations between the nutritional status and serum nutritional index and motor symptoms among patients with Parkinson’s disease(PD).…Use of safinamide: A clinical practice review of 2 year experience
Objective: Review the clinical use, efectivity and side efects in a population based cohort. Background: Safinamide is an oral, once a day adjunctive therapy for…CLOVER-DBS: A Prospective, Multi-center Clinical Study with Blinding to Evaluate a Closed Loop Programming Algorithm for Directional Leads Based on External Feedback
Objective: To assess the feasibility and efficacy of a novel closed-loop programming algorithm (CLPA) for directional lead deep brain stimulation (DBS) based on objective feedback…Design of a Phase 3 Efficacy and Safety Trial of Accordion Pill™ Carbidopa/Levodopa for Parkinson’s Disease (PD) Patients Experiencing Motor Fluctuations
Objective: To review the design and unique features of an ongoing phase 3 trial of a gastric-retentive formulation of carbidopa/levodopa (CD/LD), the Accordion Pill™ (AP),…Oral treatment with sphingosine-1-phosphate receptors modulator prevents Parkinson symptoms concomitantly to reduced brain inflammation in MPTP mouse models
Objective: Here we explore the efficacy of an oral treatment with Fingolimod (FTY720), a selective sphingosine-1-phosphate receptors modulator, to prevent MPTP induced nigrostriatal loss and…Levodopa Effect on Dual-Tasking in Freezing of Gait in Parkinson’s Disease
Objective: To assess the effect of levodopa on dual-tasking in situations triggering freezing of gait (FOG) in Parkinson’s disease (PD). Background: The frequency and severity…The effects of treadmill training augmented by virtual reality on postural control and freezing of gait in Parkinson’s disease
Objective: To investigate whether treadmill training with virtual reality is beneficial both for Parkinson’s disease patients with and without freezing of gait (FOG) to address…Correlation between severity of disease, spatio-temporal variables, and kinematic variables during forward and backward walking
Objective: The purpose of this study was to analyze the correlation between disease severity and variable by using spatio-temporal and kinematic variables during forward and…Effects of Intensive Voice and Articulation Treatments on Voice Quality in Parkinson’s disease
Objective: This study evaluated the impact of voice treatment (LSVT LOUD) and articulation treatment (LSVT ARTIC) on voice quality in Parkinson's disease (PD) measured by…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.