Combined administration of A2A receptor antagonist and 5-HT1A/1B receptor agonist reverses neuroinflammation in the 6-OHDA model of Parkinson’s disease
Objective: To investigate whether in a model of Parkinson's Disease (PD), an early treatment with the serotonin 5-HT1A/1B receptor agonist eltoprazine and the adenosine A2A…Clinical trial protocol: Restitution of oral transport, penetration and aspiration with nigral stimulation in Parkinson’s disease?
Objective: In this randomized controlled clinical trial, we aim to characterize the differential effect of subthalamic nucleus (STN) or subthalamic nucleus and substantia nigra pars…ODM-104 and optimized carbidopa dose show beneficial effect on levodopa PK in healthy subjects
Objective: To study the dose effects of a novel catechol-O-methyl transferase (COMT) inhibitor ODM-104 and the aromatic L-amino acid decarboxylase (AADC) inhibitor carbidopa on levodopa…The NIC-PD-study –A randomized, placebo-controlled, double-blind, multi-centre trial to assess the disease-modifying potential of transdermal nicotine in early Parkinson‘s disease in Germany and N. America
Objective: To evaluate the disease modifying potential of transdermal (TD) nicotine in early Parkinson’s disease (PD). For this explanatory purpose, the primary endpoint was the…What makes a successful Phase 2 study: An evaluation of Parkinson’s neuroprotective trial design over the last 5 years
Objective: To evaluate variation in Phase 2 and 3 Parkinson’s disease (PD) neuroprotective trial designs and identify key trial design features in Phase 2 studies…Remotely supervised home-based aerobic exercise for Parkinson patients
Objective: To evaluate: (1) the adherence to long-term home-based aerobic exercise (AE) in patients with Parkinson’s disease (PD); and (2) whether AE affords clinically relevant…Clinical characterization of Pramipexole induced edema and skin reaction in Parkinson’s Disease (PD) after one year of follow up
Objective: We report four patients with PD treated several years with irregular and progressively higher doses of pramipexole who presented with extensive chronic bilateral lower…Ondansetron, a highly-selective 5-HT3 receptor antagonist, alleviates L-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson’s disease
Objective: To determine the effectiveness of selective serotonin 3 (5-HT3) receptor blockade at reducing the severity of established, and preventing the development of, dyskinesia. Background:…The Effect of Short Pulse Width Settings on Speech in Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s disease
Objective: To compare perceptual characteristics and intelligibility of speech in Parkinson's Disease (PD) patients with Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) in the acute setting…Effects of Korean Medicine on Postural Instability and Gait Difficulty in Patient with Parkinsonism
Objective: The purpose of this study was to investigate the effects of Korean Medicine on postural instability and gait difficulty (PIGD) in patient with parkinsonism.…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.