Using cognitive computing to identify compounds with antidyskinetic potential for Parkinson’s disease
Objective: IBM Watson for Drug Discovery (WDD) is a platform that analyzes vast quantities of scientific data to help researchers identify hidden connections and formulate…Onabotulinumtoxin A (Botox) displays superior activity to incobotulinumtoxinA (Xeomin) in multiple in vitro and in vivo assays
Objective: This study was conducted to assess in vivo and in vitro activity of 50 U, 100 U, and 200 U vials of incobotulinumtoxinA (Merz,…Mechanisms of sub-anesthetic ketamine infusions to reduce L-DOPA-induced dyskinesia: effects on striatal mTOR signaling and beta band oscillations in striatum and motor cortex
Objective: To evaluate mechanism of long-term activity of sub-anesthetic ketamine infusion to reduce L-DOPA-induced dyskinesia (LID). Background: We have published preclinical evidence and patient case…Does levodopa-carbidopa intestinal gel in Parkinson’s disease patients increase the risk on polyneuropathy?
Objective: To analyze the influence of the overall levodopa exposure on the risk of polyneuropathy (PN) in levodopa-carbidopa intestinal gel (LCIG)-infusion treated patients with Parkinson’s…Basal Ganglia and Limbic Striatal Regions are Differentially Affected by Pramipexole: D3 receptor – Mediated Changes in Markers of Synaptic Strength
Objective: To determine whether pramipexole (PPX) differentially upregulates AMPA receptor trafficking in limbic vs. motor striatal regions of rats. Background: Impulse control disorders (ICD) are…All-trans-retinoic Acid pretreatment exhibits neuroprotective effect against 6-hydroxydopamine-induced hemi-parkinsonian rats
Objective: This study examined the effect of pretreatment with All-trans-retinoic Acid (ATRA) on the 6-hydroxydopamine-induced Parkinsonism in Wistar rats in order to find out whether…Piperine potentiate the neuroprotective effect of quercetin against MPTP induced neurotoxicity in rats
Objective: (1) Quercetin is well tolerated bioflavonoid used as supplement for various disorders but problem is its low oral bioavailability and (2) Piperine is combined…Protective effect of Myristicin against neurodegeneration in a 6-hydroxydopamine induced model of Parkinson’s disease in rats
Objective: This study examined the effect of pretreatment with Myristicin on the severity of 6-hydroxydopamine-induced Parkinsonism in Wistar rats in order to find out whether…The clinically-available anti-depressant mirtazapine alleviates both psychosis and dyskinesia in the MPTP-lesioned marmoset
Objective: To determine the effect of mirtazapine, a clinically-available anti-depressant, on psychosis and dyskinesia in Parkinson’s disease (PD). Background: Psychosis and dyskinesia cause significant morbidity…The highly-selective mGluR2 positive allosteric modulator LY-487,379 alleviates L-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson’s disease
Objective: To determine the effectiveness of highly-selective metabotropic glutamate 2 receptor (mGluR2) activation at alleviating and preventing the development of L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia. Background: Chronic…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.