Duodopa for the treatment of severe restless legs syndrome
Objective: To describe the outcome of a patient with restless legs syndrome (RLS) and augmentation phenomena that was treated with Duodopa in continuous infusion. Background:…Systematic review and meta-analysis of randomized controlled trials to evaluate placebo response in restless legs syndrome
Objective: To quantify the magnitude of the placebo response in restless legs syndrome (RLS). Background: RLS is a common sensorimotor disorder characterized by an urge…A homozygous loss-of-function mutation in DNAJA3 causes hereditary motor and sensory neuropathy with spastic paraplegia (HMSN type V)
Objective: To identify a genetic cause for hereditary motor and sensory neuropathy with spastic paraplegia (HMSN type V). Background: Hereditary spastic paraplegia (HSP) constitutes a…A phase 3, placebo-controlled study with an open-label extension: Sustained incobotulinumtoxinA efficacy in upper-limb post-stroke spasticity over 48 weeks
Objective: To assess the efficacy and safety of incobotulinumtoxinA for upper-limb post-stroke spasticity. Background: Botulinum toxin injections are a recommended therapy for limb spasticity. We…Safety and efficacy of escalating doses of incobotulinumtoxinA (400-800U): Increasing improvements in disability due to multifocal upper- and lower-limb spasticity
Objective: To assess the safety and efficacy of escalating incobotulinumtoxinA doses (400-800U) in patients with spasticity. Background: Botulinum toxin treatment at higher doses than currently…SPAsticity in PractiCE (SPACE) – An international, observational study of botulinum toxin type A in spasticity
Objective: To collect real-world routine clinical practice data on effectiveness, safety, and quality of life (QoL) for botulinum toxin type A (BoNT-A) treatment of focal…Muscle selection patterns for injection of onabotulinumtoxinA in adult patients with post-stroke lower-limb spasticity influence outcome: Results from a double-blind, placebo-controlled phase 3 clinical trial
Objective: The objective of this analysis is to identify an optimal muscle selection pattern for onabotulinumtoxinA injection for the treatment of post-stroke lower-limb spasticity (PSLLS).…Spastic gait and mechanical energy recovery in children with hereditary spastic paraplegia
Objective: We aimed to address spastic muscle behavior under dynamic conditions in children with hereditary spastic paraplegia (HSP). Background: HSPs are a clinically and genetically…Hemi-stereotypies symptomatic to aneurysm: Differential diagnosis of tardive dyskinesia
Objective: Below we present the case of a hemi-stereotypies symptomatic to aneurysm of the middle cerebral artery presented in mass effect on the subthalamic nucleus…A pilot study of SD-809 (deutetrabenazine) in tics associated with Tourette syndrome
Objective: This study explored the safety, tolerability and preliminary efficacy of SD-809 (deutetrabenazine) in adolescents with moderate to severe tics associated with Tourette syndrome (TS).…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.