Impact of chronic LD treatment on metabolism, blood flow and blood-brain barrier permeability in the 6-OHDA rat model
Objective: To determine the effects of chronic LD treatment and induction of dyskinesias on cerebral metabolism, blood flow and blood-brain barrier permeability in 6-OHDA rat…Multi-modal imaging in Parkinson’s disease patients with freezing of gait
Objective: The objective of the current study is to refine understanding of the pathophysiological mechanisms underlying freezing of gait (FOG) in Parkinson's disease (PD) using…Diffusion tensor metrics of thalamic degeneration and postural instability in Parkinson’s disease
Objective: The purpose of our study was to assess the relationship of diffusion tensor imaging (DTI) metrics and motor outcomes, with a specific emphasis on…Dopamine and task-dependent evolution of oscillatory activity in the subthalamic nucleus (STN) and coupling between the STN local field potential and muscle activity in Parkinson’s disease
Objective: To investigate how subthalamic nucleus local field potentials (STN-LFP) and coupling between STN-LFP and electromyogram (EMG) in static and phasic movements are modulated by…Cortical excitability in patients with Parkinson’s disease on levodopa carbidopa intestinal gel thereapy
Objective: To assess whether there are changes in short interval intracortical inhibition (SICI) that reflect changes in motor function and plasma levodopa levels in patients…Impaired temporal coupling of action and perception in Parkinson’s disease
Objective: To study in Parkinson's disease (PD) the dependence of saccadic and perceptual reaction times (SRT and PRT) upon the temporal asynchrony (TA) between central…Alterations in muscle synergies in early stage Parkinson’s disease
Objective: Identify whether muscle synergies are altered in stage I Parkinson's disease (PD). Background: Muscle synergies have been proposed as a mechanism utilized by the…In vivo MRI detection of Parkinson’s disease associated degeneration in the lateral ventral tier of substantia nigra pars compacta
Objective: To test a novel multimodal MRI approach for in vivo assessment of the subregion of substantia nigra pars compacta (SNpc) most vulnerable to Parkinson's…Lessons-experienced in the creation of a global public-private consortium with the goal of advancing treatments that hold most potential for delayed disease progression in Parkinson’s disease – Critical path for Parkinson’s (CPP)
Objective: The path is summarized that led to the creation of a global public-private-partnership uniting an international non-profit charity, Parkinson's UK, a global non-profit organization,…Detection of primary olfactory cortex dysfunction in early-stage Parkinson’s disease
Objective: To detect the functional changes of primary olfactory cortex (POC) in the early-stage Parkinson's disease (PD) using functional magnetic resonance imaging (fMRI). Background: Olfactory…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.