Parkinson’s Disease Dogs to assist Gait Impairment: A Pilot study of Patient Experience and Outcomes
Objective: This pilot study was designed to evaluate Parkinson's disease assistance dogs as a novel non-pharmacological therapy for gait impairment in Parkinson's disease Background: Gait…Results From a Dose-Blinded, Phase II Extension Study Evaluating Long-Term Efficacy, Safety and Tolerability of Minzasolmin in Participants With Parkinson’s Disease
Objective: ORCHESTRA XT (PD0055; NCT05543252) was a Phase II, dose-blinded extension of the ORCHESTRA Phase II, proof-of-concept study (NCT04658186). ORCHESTRA XT assessed the pharmacodynamic effects of…Non-motor Symptoms in Parkinson Disease: A Target for Neuropalliative Care Intervention
Objective: To identify various non-motor symptoms experienced by individuals with PD and to assess the likelihood of these symptoms being treated relative to individuals without…Functional and Biomechanical characterization through the progression of Parkinson’s Disease
Objective: To describe clinical, electromyographic, and gait kinematic parameters throughout Parkinson’s disease (PD) progression Background: PD is the second most prevalent neurodegenerative disease worldwide. Classic…Gym Strength Training for People with Early Onset Parkinson’s disease
Objective: For adults living with early onset Parkinson’s disease (EOPD) to evaluate the feasibility, safety and acceptability of a gym-based resistance strength training exercise program…Caregiver Burden after DBS at GPI or STN for Parkinson’s Disease
Objective: Examine the effects of GPi or STN DBS on caregiver burden for Parkinson's Disease Background: Deep Brain Stimulation (DBS) is a common treatment used…Impact of Cognition on Social Engagement in Community-based Older Adults with Parkinsonism
Objective: To investigate how cognition and gait influence social engagement in parkinsonism. Background: Social engagement is vital to quality of life in parkinsonism, yet the…Cerebrospinal fluid DOPA decarboxylase levels as a marker of disease severity in Parkinson’s Disease
Objective: To assess the correlation of CSF DDC levels to DaT-SPECT SBR in PD and iRBD. Background: Raised cerebrospinal fluid (CSF) proteomic biomarker, DOPA decarboxylase…G-Can, the GBA1 Canada Initiative
Objective: G-Can, the GBA1 Canada Initiative, is an open-science platform which aims to advance GBA1 research and develop treatments for GBA1 mutation-related Parkinson's disease (PD).…Pharmacokinetic Analysis of Subcutaneous Levodopa/Carbidopa Delivery With ND0612
Objective: To (i) use a population pharmacokinetic (PK) model to compare predicted levodopa PK parameters when levodopa is delivered as investigational ND0612, as oral immediate-release…
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