NIH funds Gut-Brain Parkinson’s Disease Consortium
Objective: Describe the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) multicenter (UO1) Consortium on PD Gut-Brain Communication. Background: A 2024 Notice of Funding…Advancements in Microbiome Research: Total Microbial Load, Differential Absolute Abundance, and Correlations with Immune Transcriptomics
Objective: Quantify total microbial load in the gut microbiome of people with Parkinson’s disease (PD) and compare the absolute abundance of bacterial taxa between PD…Does the cerebellum compensate to enable motor learning in Parkinson’s Disease?
Objective: To test the causal relation between cerebellar function and learning in PD. Background: Neuroimaging studies reveal that people with Parkinson’s disease (PwPD) exhibit increased…Coping with Parkinson’s Disease through the Lens of Personality Systems Interactions (PSI) Theory: Two Case Studies
Objective: This study examines how concepts from motivation and personality research contribute to understanding coping strategies in individuals with Parkinson’s disease (PD). Background: Effective treatment…Cognitive Load Modulates Excitability of Subthalamic Motor Circuitry in Parkinson’s Disease
Objective: To characterize the effect of cognitive load on the excitability of circuitry connected with the subthalamic nucleus (STN) motor territory in Parkinson’s disease (PD)…GBA Mutations Alter Subthalamic and Nigral Neural Activity in Parkinson’s Disease
Objective: To investigate the neurophysiological basis of Parkinson’s disease (PD) in patients with glucocerebrosidase (GBA) mutations. Background: Alterations in subthalamic neural activity are associated with…Solengepras: An Investigational Therapy with Potential Benefits on Functional and Non-Motor Measures in Parkinson’s Disease (PD)
Objective: Solengepras is a GPR6-inhibitor that is being studied as an investigational treatment for Parkinson’s Disease (PD). Background: GPR6 is a novel G-protein-coupled receptor found…Long-term effects of a periodic intensive rehabilitation program in People with Parkinson’s Disease
Objective: This study aimed to examine the long-term effects of a periodic intensive rehabilitation program incorporating tele-tools on the progression of motor symptoms in people…Exploring Clinical and Neurophysiologic Predictors of Adaptive Deep Brain Stimulation Response in Parkinson’s disease
Objective: To evaluate clinical and neurophysiologic characteristics that may predict a positive clinical response to adaptive deep brain stimulation (aDBS) in patients previously stable on…Methodological considerations supporting a time-to-event primary endpoint in the PADOVA study in early-stage Parkinson’s disease participants on stable symptomatic treatment
Objective: To provide the methodological rationale for using a time-to-event (TTE) primary endpoint in the PADOVA study. Background: The use of symptomatic medications represents a…
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