Investigation of superficial brain stimulation (SBS) in Parkinsonian rats as a non-invasive alternative treatment for patients with movement disorders
Objective: To investigate repetitive transcranial magnetic stimulation (rTMS) in parkinsonian rats as a non-invasive, malleable superficial brain stimulation (SBS) alternative to DBS. Background: DBS is…Differential effect of MAPT haplotype on survival in CBD and PSP-SCB phenotype
Objective: Evaluate the association of MAPT haplotype with the risk of PSP-CBS and CBD severity of tau pathology by studying the survival rate of both…18f-PI-2620 tau PET neuroimaging, tau protein burden and 18f-PI-2620 tau autoradiography on human postmortem brain tissue in a PSP patient
Objective: Our aim is to describe the findings of 18F-PI-2620 tau-PET imaging, together with tau protein burden and 18F-PI-2620 tau autoradiography in brain tissue from…Investigate the association of MAPT haplotype and neuroanatomical structure and its influence on the risk of Parkinson’s disease
Objective: To investigate if the vulnerability of Parkinson’s Disease (PD) can be reflected in the neuroanatomical structure in different MAPT haplotype carriers. Background: It has…A randomized, phase 2a, double-blind, placebo-controlled clinical trial with NE3107 adjunctive to carbidopa/levodopa in patients with Parkinson’s disease
Objective: To evaluate the motor effects of NE3107 treatment in patients with levodopa-treated Parkinson’s disease (PD) experiencing motor fluctuations. Background: NE3107 is an oral, blood-brain…Development of potent, orally bioavailable, and highly selective LRRK2 PROTAC® degrader molecules as potential disease modifying therapeutics for Parkinson’s disease
Objective: Report on the pharmacological characteristics of small molecule PROteolysis TArgeting Chimera (PROTAC) molecules designed to induce degradation of leucine rich repeat kinase 2 (LRRK2)…Hemidystonia of cerebellar origin
Objective: To report the case of a patient developing hemidystonia in the course of cerebellar hemorrhage. Background: About 1-4% of strokes may include movement disorders,…Prevalence and clinical characteristics of young onset Parkinson’s Disease among Nepalese Population
Objective: To know the prevalence and clinical characteristics of young onset Parkinson’s Disease among Nepalese Population Background: Parkinson’s disease (PD) is a neurodegenerative disease which…Regional brain volume and cognitive alterations in Huntington’s Disease Patients
Objective: To investigate i) HD patterns of cortical and subcortical atrophies ii) associations between atrophy and clinical, motor and cognitive features. Background: Huntington’s disease (HD)…Istradefylline therapy for PD plus oromandibular dystonia
Objective: To clarify the dopaminergic system link between parkinson's disease (PD) and oromadibular dystonias (OMDy) co-occur, and the effect of istradefylline (IST) therapy. Background: OMDy are…
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