MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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  • 2025 International Congress

    Sex Differences in α-Synuclein Seed Amplification Assay Parameters and Longitudinal Clinical Subtypes of Parkinson’s Disease

    SM. Fereshtehnejad, J. Lökk (TORONTO, Canada)

    Objective: To investigate differences in baseline α-synuclein seed amplification assay (SAA) metrics and longitudinal clinical subtypes of Parkinson’s disease (PD) between the two biological sexes.…
  • 2025 International Congress

    Eye movement abnormalities in GBA1-related Parkinson’s disease and non-manifesting GBA1-carriers

    G. Riboldi, T. Hudson, H. Conn, K. Astudillo, J. Rizzo, S. Frucht, J. Rucker (New York, USA)

    Objective: To perform an in-depth characterization of eye movement abnormalities in Parkinson’s disease (PD) and non-manifesting carriers of GBA1 pathogenic variants. Background: Eye movement abnormalities…
  • 2025 International Congress

    Distinct Peripheral Immune Profiles of Parkinson’s Disease and Multiple System Atrophy

    S. Jo, I. Jang, J. Lee, M. Choi, E. Lee, SJ. Chung (Seoul, Republic of Korea)

    Objective: We aimed to compare peripheral blood mononuclear cell (PBMC) subsets between Parkinson’s disease (PD) and multiple system atrophy (MSA) to identify disease-specific immune signatures…
  • 2025 International Congress

    Facial Blendshape Index(FBI) for Quantification of Hypomimia on Parkinson´s Disease

    B. Koyak, T. Menzel, M. Botsch, A. Spottke, M. Reuter, U. Wüllner, NA. Aziz (Dortmund, Germany)

    Objective: To evaluate the validity of ExpressionTracker, an app generating personalized facial blendshapes, for objective quantification of hypomimia in patients with Parkinson’s disease (PD) [1].…
  • 2025 International Congress

    Dried Plasma Spot Cards for Measurement of Neurofilament Light Chain

    B. Huxford, P. Gklinos, F. Rios, N. Vickaryous, L. Schalk, A. Noyce, R. Dobson (London, United Kingdom)

    Objective: Evaluate measurement of neurofilament light chain (NfL) in dried plasma spot cards, and to compare these to measurements using more invasive and in person…
  • 2025 International Congress

    AntiSaccadeNet: A Deep Learning Framework for Differentiating Parkinsonian Disorders through Antisaccade Time Series Classification

    S. Patel, C. Antoniades, J. Fitzgerald, O. Bredemeyer (Oxford, United Kingdom)

    Objective: To develop and evaluate a deep learning architecture (AntiSaccadeNet) that utilizes continuous antisaccade eye movement time-series data to differentiate between Parkinson's disease (PD) and…
  • 2025 International Congress

    Phase 1 and 1b Pharmacodynamic Data Support Central Modulation of Lysosomal Pathways With BIIB122/DNL151, a LRRK2 Kinase Inhibitor: Insights for the LUMA Trial

    K. Fraser, A. Lang, L. Kalia, R. Hauser, J. Greenamyre, Y. Moroishi, J. Kluss, B. Hersh, K. Ferber, R. Maciuca, C. Paián-Ruiz, R. Llorens-Arenas, D. Jennings, S. Huntswork-Rodriguez, D. Graham (Tampa, USA)

    Objective: Evaluate the effects of BIIB122/DNL151 treatment on CSF levels of pRab10, a biomarker of CNS LRRK2 modulation, in a Phase 1 study in healthy…
  • 2025 International Congress

    Barriers to Healthcare Utilization and Adherence to Medications among People Living with Parkinson’s Disease in Senegal

    M. Njohjam, M. Fall, F. Niakam, J. Kahwagi, A. Diop, M. N, A. Diop (Dakar, Senegal)

    Objective: To explore the barriers to healthcare utilization and adherence to medications among people living with Parkinson’s disease in Senegal, and propose context-informed strategies to…
  • 2025 International Congress

    Broad spectrum local field potential activities as a novel biomarker for adaptive deep brain stimulation

    CH. Tai, YC. Lin, WH. Hu, MT. Hsu, SH. Tseng (Hsinchu, Taiwan)

    Objective: This study aims to evaluate the wider frequency range (1-200 Hz) LFPs as the novel neural biomarkers for adaptive DBS. In parkinsonism rats, we…
  • 2025 International Congress

    Investigation of cortex – basal ganglia pathways with cortical stimulation and subthalamic evoked responses in patients with Parkinson’s disease

    J-C. Beyer, A. Cavallo, R M. Köhler, J. Vanhoecke, G-H. Schneider, A A. Kühn, W-J. Neumann (Berlin, Germany)

    Objective: To investigate the electrophysiological interplay between the human cortex and the subthalamic nucleus (STN) by comparing STN responses to direct cortical electrical stimulation and…
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