Privacy and Personalisation: Predicting Parkinson’s Severity with Federated Learning
Objective: To improve privacy and personalisation for artificial intelligence (AI), this work compared federated learning (FL) to a conventional, centralised system for predicting Movement Disorder…Phosphorylated High Mobility Group Box Protein 2 (HMGB2) as a Potential Biomarker for Parkinson’s Disease
Objective: We recently showed that HMGB2 is secreted during ferroptosis and as ferroptosis is involved in the etiology of PD, we have examined the possibility…Monitoring Parkinson’s Disease in the Dental Chair
Objective: Our goal is to bridge the mechanistic knowledge gap on the Microbiota-Gut-Oral-Brain-Axis (MGOBA)’s role in Parkinson’s disease (PD) pathogenesis through a case-control, proof-of-concept, observational…Novel Insights into the Association Between Parkinson’s Disease and Constipation: Role of SHMT2 as a Promising Biomarker
Objective: This study aims to analyze the shared molecular pathways between Parkinson’s disease (PD) and constipation through integrative bioinformatics methodologies and further validate candidate biomarkers…Lysosomal Lipid Dysregulation in Parkinson’s Disease: Genetic and Medication Effects in CSF Metabolomics
Objective: Define lipid signatures in sporadic, LRRK2, and GBA1 PD and pre-manifest carriers and assess medication impacts. Background: Lysosomal dysfunction contributes to PD, particularly in…Low-frequency pallidum evoked potential dynamics as a prospective biomarker for Parkinson’s disease
Objective: Characterize low-frequency evoked potential (EP) activity induced by deep brain stimulation (DBS) in the internal globus pallidus (GPi) and how the EP dynamics modulate…The Moroccan LRRK2 Registry: Building Resources to Investigate the Penetrance and Phenotype of LRRK2 in North Africans
Objective: The Moroccan LRRK2 Registry aims to establish a comprehensive database integrating clinical data and biosamples to provide valuable insights into the penetrance, phenotype, and…Predicting Parkinson’s disease severity and cognitive decline using blood-based ferroptotic biomarkers
Objective: As Parkinson’s disease progresses, patients require second-line treatments such as subthalamic stimulation, the benefits of which may be undermined by the appearance of non-dopaminergic…Barriers to Healthcare Utilization and Adherence to Medications among People Living with Parkinson’s Disease in Senegal
Objective: To explore the barriers to healthcare utilization and adherence to medications among people living with Parkinson’s disease in Senegal, and propose context-informed strategies to…Metabolomic breath landscape analysis unravels lipid biomarker candidates in patients with monogenic and idiopathic Parkinson’s disease
Objective: We propose an untargeted metabolomics approach using exhaled breath analysis to (1) characterize the non-volatile metabolomic breath signature of Parkinson’s disease (PD) patients with…
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