Evaluation of a novel Phosphodiesterase 5 inhibitor as a potential therapeutic agent in P301S transgenic mouse model of tauopathy.
Objective: In the current study, we evaluated a newly developed compound with a 1,3,5-trisubstituted pyrazoline scaffold with an improved PDE5 inhibitory potency as a potential…Drug-induced Parkinsonism and nonmotor symptoms: a case of gustatory rhinorrhea
Objective: We aim to emphasize the relevance of contemplating nonmotor symptoms as possible features of drug-induced parkinsonism, and the utmost importance of further investigation in…Childhood-onset writer’s cramp evolving to generalised dystonia –a new mutation in KMT2B gene
Objective: To present a case of childhood-onset dystonia with a new mutation in KMT2B gene. Background: KMT2B-related dystonia (DYT-KMT2B) is an increasingly recognized cause of…Diabetic striatopathy presenting without hyperkinetic movements
Objective: To demonstrate a case of Diabetic striatopathy presenting without hyperkinetic movements Background: Diabetic striatopathy is an uncommon neurological complication associated with poorly controlled Diabetes Mellitus…Stiff-Person Syndrome: Diagnosis and Experimental Models
Objective: Locked-in syndrome is a syndrome that is characterized by the lack of an adequate response of the patient to external, including verbal, stimuli due…A randomized, phase 2a, double-blind, placebo-controlled clinical trial with NE3107 adjunctive to carbidopa/levodopa in patients with Parkinson’s disease
Objective: To evaluate the motor effects of NE3107 treatment in patients with levodopa-treated Parkinson’s disease (PD) experiencing motor fluctuations. Background: NE3107 is an oral, blood-brain…Linking volume of tissue activated to neural oscillations in deep brain stimulation
Objective: Exploring the effect of deep brain stimulation (DBS) settings on neural oscillations in Parkinson’s disease (PD) patients with subthalamic nucleus (STN) DBS and their…Differential effect of MAPT haplotype on survival in CBD and PSP-SCB phenotype
Objective: Evaluate the association of MAPT haplotype with the risk of PSP-CBS and CBD severity of tau pathology by studying the survival rate of both…A comparison of national data on Parkinson’s disease mortality between the USA and UK
Objective: To evaluate recent mortality trends in Parkinson’s Disease (PD) between the United States of America (USA) and the United Kingdom (UK) per national healthcare…3D Multi-Delay pCASL to Understand Perfusion Changes in Patients with Parkinson’s disease with Mild Cognitive Impairment
Objective: To understand perfusion changes in patients with Parkinson’s disease (PD) with well-characterized mild cognitive impairment (MCI) using 3D multi-delay pseudo-continuous Arterial Spin Labeling (pCASL)…
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