Alterations of gait as an early marker of incipient alpha-synucleinopathy
Objective: To investigate early motor signs of α-synucleinopathies in patients with isolated REM sleep behavior disorder (iRBD) using gait analysis. Background: iRBD is an early…RNA editing contributes to the inflammatory astrocytic response in Parkinson’s disease.
Objective: 1) Using an IPSC derived cell model to explore astrocytic responses alone and cocultured neurons to alpha-synuclein oligomer (αsynO) treatment.2) Determine the extent to…Effect of variants in COMT and UGT1A genes on clinical response in patients with Parkinson’s disease treated with opicapone
Objective: To identify genetic variants associated with different clinical responses in patients with Parkinson’s disease(PD) treated with opicapone. Background: Opicapone is a catechol‐O‐methyltransferase(COMT) inhibitor used…Efficacy of perampanel in paroxysmal kinesigenic dyskinesia
Objective: To explore the efficacy and safety of perampanel in the treatment of paroxysmal kinesigenic dyskinesia (PKD) Background: Perampanel is a new type of antiepileptic…An European-Canadian multinational evaluation of access to care in Parkinson disease: a patient perspective
Objective: To provide a multi-national perspective of people with Parkinson disease (PwPD) on access to healthcare and the impact of the COVID-19 pandemic on those…Individual-specific brain functional connectivity mapping of therapeutic response in task-specific focal dystonia
Objective: Determine therapeutic effects of botulinum toxin on functional connectivity in individuals with task-specific dystonia. Background: Isolated task-specific dystonia occurs during specific activities, but not…Motor subtype stability and cognitive profiles in early Parkinson’s disease
Objective: To examine the association between motor subtypes’ stability and cognitive assessment scores across three years in early Parkinson’s disease (PD). Background: Past studies have…Hearing impairment and non-motor symptoms in Parkinson’s disease: association and impact on quality of life
Objective: The aim of the study was to investigate the possible correlation between non-motor symptoms (NMS) burden and quality of life (QoL) with hearing impairment…Effect and Mechanism of Shaoyao Gancao Decoction(SGD) in Treatment of Pain in Parkinson’s Disease Based on Network Pharmacology and Molecular Docking
Objective: Based on the method of network pharmacology, this paper discusses the potential effects and mechanisms of SGD in the treatment of pain in PD. Background:…Gender differences in REM Sleep Behavior Disorder in Parkinson’s disease
Objective: To study the gender differences in probable REM Sleep Behavior Disorder (RBD) and other sleep characteristics in a cohort of Parkinson’s disease (PD) patients.…
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