Longitudinal Exercise is Associated with Reduced Hospitalization Risk in Parkinson’s Disease
Objective: To determine if longitudinal exercise and physical therapy (PT) use is associated with reduced risk of hospital encounter in individuals with Parkinson’s disease (iwPD).…Analyzing early states of HD progression using a machine learning driven approach
Objective: Our aim is to build an early state HD progression model (EHDPM), a sub-model to Integrated Huntington’s Disease Progression Model (IHDPM) [1] to identify…Neuroprotective effects of Ibudilast, a Phosphodiesterase IV inhibitor in mouse model of Parkinson’s disease
Objective: In the present study, we examined neuroprotective effects, if any, of IBD drug, a inhibitor of the phosphodiesterase IV in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse…Frequency dependent interindividual variability of the deep brain stimulation effect on upper-limb bradykinesia
Objective: To demonstrate that there are interindividual differences in the response of upper limb bradykinesia to subthalamic deep brain stimulation (STN-DBS) in patients with Parkinson’s…The shaky truth of a Movement Disorder Nurse pilot program in Rural Australia
Objective: The conception of the Movement Disorder Nurse program began when the Australian Government and Fight Parkinson’s conducted a scoping evaluation of people living with…Predictors of loss to follow-up three years after inclusion in a prospective longitudinal cohort study in people with early Parkinson’s disease
Objective: To investigate potentially modifiable predictors of loss to follow up (LTFU) three years after inclusion in a nationwide mono-centric Parkinson’s cohort study. Background: LTFU…Predictors of relapse in impulse control disorders in patients with Parkinson’s disease.
Objective: Identify predictors of relapse in impulse control disorders (ICD) in patients with Parkinson's disease. Background: Behaviors that are performed repeatedly, excessively or minimally and…Microglial activation facilitates alpha synuclein propagation and neurodegeneration in αSyn preformed fibrils (PFF)-injected PD mouse model
Objective: To evaluate whether microglial activation aggravates synucleinopathy progression in Parkinson's disease (PD) mouse model. Background: Alpha-synuclein (αSyn) accumulation underlay the main pathological process of…Effect of lower limb vs. abdominal compression on mobility in orthostatic hypotension – a single-blinded, randomized, controlled, cross-over study in Parkinson’s disease
Objective: Orthostatic hypotension (OH) in Parkinson’s disease (PD) is frequent and associated with reduced quality of life and reduced activities of daily living. Abdominal binders…Development of a quality-of-life (QoL) questionnaire for hereditary spastic paraplegia (HSP) patients and caregivers.
Objective: Patient reported outcomes like “Health-Related Quality of Life” are one of the key outcome parameters of clinical studies. The aim of this project within…
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